It has previously been delivered by some of the most prominent names in broadcasting including Jeremy Paxman, Mark Thompson, and Rupert Murdoch and his son James.
Reporters in Jerusalem and Ramallah spoke to local people about their hopes for the summit and international editors Mark Mardell and Jeremy Bowen analysed the diplomatic repercussions.
At Comic-Con Downey took the stage and introduced Mark Ruffalo as The Incredible Hulk, Jeremy Renner (from The Hurt Locker) as Hawkeye and the relatively unknown stars of the upcoming films Thor and Captain America.