One man who knows all about waiting for a first grand slam title is Ivanisevic.
CNN: Tennis legends tip Murray for grand slam glory at U.S. Open
Federer will next meet Gustavo Kuerten, who beat Goran Ivanisevic 6-2 6-4 to reach the second round.
Kuerten hit 20 winners to Ivanisevic's 11 and made just 15 unforced errors to his opponent's 24.
After five games had gone with serve in the third, Ivanisevic broke Rafter brilliantly with two wonderful returns.
So it's a big achievement for her and she's going to be up there with tennis star Goran Ivanisevic.
Ivanisevic called for the doctor, grimacing as his troublesome left shoulder stiffened up.
Jelena Gencic, who also worked with grand slam champions Monica Seles and Goran Ivanisevic, was 77 when she passed away.
Youzhny made an edgy start, losing his first service game, and that proved decisive as Ivanisevic served out the set.
My third defeat was probably the hardest, when I lost to the unseeded Goran Ivanisevic after three rain affected days.
"All he had to do was beat Ivanisevic and he would doubtless have gone on to win the final, " I said.
Ivanisevic had accelerated into the opening set, holding his serve with ease and then breaking a nervy Rafter at the first attempt.
Two rain breaks in the second set disrupted Ivanisevic's rhythm but some careful baseline rallying in the tie-break forced errors from Youzhny.
"I have to say thank you to the Wimbledon Committee for the schedule, which means I can watch the game, " said Ivanisevic.
Ivanisevic, by contrast, looked focused and duly took the set with ease.
Ivanisevic soaked up the applause before hurrying off Centre Court, presumably keen to watch his beloved Croatia take on England in Euro 2004.
Ivanisevic's usually lethal serve began to splutter, his first-serve percentage slipping to 50% - and the match was level with exactly an hour gone.
However, from the moment the crowd hailed Ivanisevic as he stepped back onto Centre Court, the former champion looked in control of the situation.
"I think Andy is ready, with or without him, " said Ivanisevic.
CNN: Tennis legends tip Murray for grand slam glory at U.S. Open
And Wimbledon champion Goran Ivanisevic is joined in the draw by Frenchman Sebastien Grosjean, who finished 2001 as world number six, and Australian Open finalist Marat Safin.
Tim Henman's great chance had come, I suggested, when he reached the semi-final in 2001 and took on Goran Ivanisevic, who was at the fag-end of his career.
The victory boosts his career record against Ivanisevic to 6-2.
Together with Mario Ancic, Goran Ivanisevic and Ivo Karlovic, Ljubicic was part of Croatia's victorious 2005 Davis Cup team, becoming the only unseeded country to win the event.
Ivanisevic came into the match with just two wins from 11 matches this year, and without a victory since March, and Youzhny was a strong favourite as world number 35.
His 2001 Wimbledon semi-final against Goran Ivanisevic, when he was two sets to one up, and his 2002 Australian Open fourth-round defeat to Jonas Bjorkman, when the draw had opened up for Henman, are two of too many examples.
The ATP Champions Tour roster now reads like a who's who of tennis with former grand slam all-time record holder Pete Sampras a recent addition, plus the likes of Goran Ivanisevic, Stefan Edberg, Richard Krajicek and Open Court's own Pat Cash.
There was an intense performance from Malawian rap act NiC, a duo who volleyed words back and forth like Sampras and Ivanisevic in their prime, deciding not to bother with those fancy passing shots and just belting the ball at each other.
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