"I know the risk and I know what happens when it goes wrong, " he told BBC World Service.
It is perhaps why commuters react with such fury, when it goes wrong.
Where it goes wrong is when loneliness becomes chronic, and the inflammatory response becomes chronic at the same time.
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For example, making vaccines more effective and turning off the immune system when it goes wrong and attacks the body in autoimmune diseases like rheumatoid arthritis, he said.
When it goes wrong, the local salt balance is upset and mucus tends to build up around the cells in question (particularly those in the gut, lungs and pancreas) with ultimately fatal results.
In the first place, because we are a highly financialised world economy, in which the destabilising role of finance - when it goes wrong - is in proportion to its highly stabilising and dynamic role when it works right.
That could be because people can't or don't want to wait for a delivery van to show up, or they are in a hurry, or they don't want to bother with a salesperson, or they know they can return what they buy if it goes wrong, or they just want to save on the delivery charge, especially if it is something heavy.
She discovered the hard way that, while critics are more than happy to see successful sport stars pull outrageous publicity stunts, it all goes wrong when you're perceived to be a show-off who can't back it up with results.
Like air, it's all around us, but we never think about it unless something goes wrong with the supply.
How much are we willing to make it a 'Lord of the Flies'-type situation if it all goes terribly wrong?
It called Mr Gill a "Captain Mainwaring" character, "fine on rousing speeches, fine on setting out tactics, but in the field it all goes horribly wrong".
It all comes back to risk: who loses if a project goes wrong, and how much they earn if it goes right.
When something goes wrong it is human nature to want to assign blame, and that feeling only intensifies among the political class as they feel a duty to hold the guilty party responsible and get justice for those wronged.
When phosphorylation goes wrong, it can cause diseases such as cancer, diabetes and arthritis.
It is when something unexpected goes wrong that a company really shows its mettle.
Modern British political culture castigates government for its over-bearing, interfering ways, yet holds it accountable whenever anything goes seriously wrong.
If it goes even a tiny bit wrong, then where and how it is manufactured suddenly starts to matter very much indeed.
Deputy Prime Minister Nick Clegg welcomed the report, telling BBC Radio 4's Today programme: "It is based on the insight that many people share, which is that it is not right to have very high-risk and very low-risk banking activities so intertwined that, when something goes wrong, it is the taxpayer that picks up the bill".
And when something goes wrong, as it did on Triumph, there are limits to how much the Coast Guard can investigate.
They made me realise that I was using drink for the wrong reasons and it goes back to you as a person, it's finding you.
So when something goes wrong, as it did recently with the steering shaft on the Prius and ten other (non-U.S.) models, the recall number is high.
Scientists don't really understand what goes wrong to cause it.
These executives always have someone they can offer as a sacrificial lamb when something goes wrong, making it appear as though all that is needed to rectify the problem is to fire the worker and all will be well in the world.
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When the core business goes wrong, companies fix it from within or lose customers and credibility.
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When something goes wrong on Firefox, it displays a message saying "Well, this is embarrassing".
When something goes wrong while flying, it can feel far more punishing than a bad hotel or unsatisfactory purchase.
Traders get paid lavishly when they make the right bet but it is always OPM when the bet goes wrong.
Every time something goes wrong, they find an employee to blame it on, and they take full credit for everything that goes right.
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