This morning, Merck announced that a clinical trial had failed to show that giving its HIV drug Isentress once-a-day was as effective as the current twice-a-day dosing schedule.
As I wrote last year, Isentress was a very difficult drug to develop, requiring more than a decade of tenacious advocacy on the part of a Merck scientist named Daria Hazuda.
The excitement about its newer medicines--including the human papillomavirus vaccine Gardasil, the diabetes pill Januvia and the yet to be approved AIDS drug Isentress--along with reduced fears about liability from Vioxx have helped carry the stock.