Novartis is closing in on the number five spot, while Roche is number nine.
The gold market is closing in on longer-term support levels, which are attractive to physical buyers.
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And now, a little over two months later, the group is closing in on 200, 000 members.
But its revenue is rising 80% a year, and its net margin is closing in on the 21% that BMC gets.
China's biggest airline is closing in on a deal for a 51% stake in the proposed cargo joint venture to be based in Shanghai.
The children's program is closing in on the kind of rarified digital milestone usually reserved for the likes of pop stars and cat videos.
Starting pitcher Andy Pettitte is closing in on his 41st birthday.
Wind is closing in on the price of coal, as well.
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It is the third year running that Federer has beaten Djokovic in New York and the top seed is closing in on a sixth straight US Open title.
Chanderpaul has now scored an aggregate of 558 runs in the series at an average of 186.0 and is closing in on captain Carl Hooper's leading total of 579.
President Obama tried Tuesday to create momentum for overhauling the nation's health care system, saying Congress is closing in on a plan that will provide care to all Americans.
According to monthly sales figures compiled by Autodata, Audi is closing in on BMW and Mercedes in the race to sell the most luxury cars on the market this year.
Now he is closing in on Spain's most prolific goalscorers in the national team's history - his captain Fernando Hierro (on 27 goals) and Emilio 'The Vulture' Butragueno on 26.
When you feel the world is closing in on you try to find some time alone - even if it is only to have a bath - and learn to say no to the demands of relatives.
And recent polling data indicate that once a long-shot candidate, Pollak is steadily closing in on Schakowsky's lead.
The YouTube channel RealAnnoyingOrange is quickly closing in on one billion views.
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And the upstart is fast closing in on critical advertising dollars.
Flanker Tom Rees, who has suffered wretched luck with injuries, is also closing in on a return from a prolonged spell on the sidelines after shoulder surgery.
But a new survey shows that Apple is actually closing in on Nintendo with respect to an important metric: total number of people actually playing games on the mobile devices.
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According to Bloomberg, Intel is getting close to offering such a service and is reportedly closing in on deals with Time Warner, Viacom and NBC that would allow them to offer both live and on-demand content over the internet.
The spread is rising and closing in on levels seen during the financial panic.
The correlation between daily changes in closing price in the two price series is 0.93, on a scale where 1.0 would tell you that one change is always a fixed multiple of the other.
Central Cornwall PCT is consulting on closing 37 beds in three cottage hospitals, which it says will be replaced with more community care.
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Boeing actually offered the Army options for scaling back features a year ago that were rebuffed, but with the budgetary walls closing in the service is now moving out on a series of efficiency measures that could unravel the whole effort.
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Of these, Latvia, Malta and Slovakia are fast closing in on the leaders, Lithuania is moving a little more slowly, while Bulgaria and Romania are lagging well behind.
That case is being challenged in federal court, and closing arguments were heard on Monday.
The Knitting Circle is currently touring English theatres, closing in Bristol's Tobacco Factory on 20 May.
The era of engineers and entrepreneurs swinging for the wall every time they stood on the stage is closing and now we are in a period of consistant base hits.
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The rest is about closing the gap and getting in front of everything to lead customers on their journey with experience at the forefront of everything in every moment of truth.
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