It is not even clear that Mr O'Neill's departure will make a significant difference in international economic policy.
Walking away now versus participating is the difference between the international community pursuing them to justice, and all the way, and a different future.
Unfortunately, it is hard to see how the IDF's efforts to convince the UN or the US that it upholds international law will make any difference.
McCain's trip to Mexico could highlight another difference between him and Obama on international trade.
The way that an international business addresses these debates can make the difference between superior and inferior performance.
It's likely to take more than one crisis, whatever its outcome, to make any long-term difference in the Taleban's international standing.
"Alessandro is an important player with great international experience and that's what makes a difference at this level, " said Berbizier.
The main difference is a small handful of major international currencies.
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And certainly there is some good international evidence that action at a local level can make a difference.
If the international community acts now, I think we can make a difference.
Even the reluctance of Lebanon and Iraq to apply full sanctions will be unlikely to make a big difference in Syria's fortunes, especially as international pressure continues to mount.
The most important difference is Israel has not agreed to have an international force stationed in Gaza as it accepted (and in Livni's case, championed) the deployment of UNIFIL forced in South Lebanon.
Second, if then we have the international force through the United Nations, or CARICOM or the U.S. in Haiti increasing the number of the international police already in Haiti, it will make the huge difference.
But the big difference between this and the December tragedy has been the international reaction.
Because of that sharp price difference, the release of crude oil reserves by the International Energy Administration was the right move, he said.
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"We really want to get the attention of international agencies, charities and national governments to show them what a difference we can make by doing something very simple, " she added.
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So in summing up George, what would you say is the difference between globalisation as we're talking about it today and international trade which we used to call it 20 years ago?
The one big difference that will keep China from crisis is that it is a large international creditor, not a debtor like the Asian crisis countries.
But perhaps the biggest difference from 1982 is that today Israel has the support of much of the international community, at least for now.
"One year doesn't make a big difference, " says Edwin Truman, a senior fellow at the Peterson Institute for International Economics and a former assistant Treasury secretary for international affairs.
What Steve Hewlett pointed out this morning on the Today programme is that there is an important difference between Mr Coulson and Ms Brooks, which is that he resigned from News International all those years ago after the original revelations about how a private detective, Glen Mulcaire, used illicit techniques to obtain private information about prominent individuals.
Based on Factsheet data from MSCI and FTSE, this difference will increase the holdings in developed market index funds and reduce the holdings in the total international fund.
"Hydropower is the cheapest electricity you can generate anywhere so Ethiopia has huge advantages for that and Ethiopia will export enough power to make a difference in the economy, " says Henock Assefa, an economist and managing partner of Precise Consult International based in Addis Ababa.
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