He leafed through the pharmaceutical bible, the Physicians' Desk Reference, and selected 300 drugs to test, culling only those for which fast-onset was a necessity, including medicine for migraines (Imitrex), allergies (Claritin) and depression (Prozac).

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In the first study, published in the journal Neurology, Dr. Kurth and his colleagues looked at 27, 798 female health professionals ages 45 and older, including 3, 568 who had migraines, from the Women's Health Study.

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Jason Lipsett, 21 years old, was diagnosed with Lyme in November, after suffering for three years with symptoms including problems with his jaw, recurring sinus infections, migraines and trouble sleeping.

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