The Russian set the tone in the first set by breaking serve in the opening game.
The 29-year-old said the early advantage in the first set helped set the tone of the encounter.
The wind was a little bit difficult, especially in the first set -- a lot of framing.
Murray had made a strong start, leading 3-1 and 40-0 in the first set before his game fell apart.
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Djokovic, meanwhile, overcame a tumble in the first set before coasting past Odesnik.
"I was a little bit nervous in the first set and part of the second, " said the 30-year-old Ferrer.
Sharapova was uncharacteristically fragile at times against Ivanovic, missing three set points while serving at 5-4 in the first set.
Nadal, who had gone past 25 seconds after another long point in the first set, with no warning, ignored it.
Groenefeld ran Clijsters close in the first set when they met this year at Stanford when the Belgian won 6-4 6-0.
Henin-Hardenne twice broke in the first set, only to be pegged back, but on the third occasion, Bremond could not recover.
Haas, 41st in the world, broke once in the first set first and then held his nerve in the second-set tie-break.
Murray was broken once in the first set but had no further problems and came through in one hour 32 minutes.
Watson, who is based in Florida, found herself 3-1 down in the first set before winning four games on the trot.
Second seed Svetlana Kuznetsova was also tested, trailing 2-5 in the first set to Bulgaria's Tsvetana Pironkova before triumphing 7-6 (7-0) 6-2.
For all of Nadal's weaknesses in the first set, he's done brilliantly to get back into this, regardless of what happens now.
Lopez, the 31st seed, made a superb start, forging a 5-2 lead in the first set before rain forced the players off.
Monfils fought hard in the first set but ended up well beaten.
The Swede had nine break points in the first set, but could take only one - when he drew level at 4-4.
Roger had a couple chances to get back in the first set and I hit a few big serves on some of them.
Murray again broke early in the second thanks to a sublime crosscourt backhand but, just as in the first set, Tipsarevic fought back.
The Swiss saved seven of those break opportunities, including five in the first set, but managed just a solitary break of serve himself.
In the first set of analysis, the team found 182 species of bacteria, but at the repeated test a further 65 showed up.
Tsonga was swept aside in the first set but quickly regained control to win 1-6 6-3 6-2 6-4 to reach the second round.
The third-seeded Henin-Hardenne raced to a 3-0 lead in the first set against Kuznetsova before being broken for the only time in the match.
The former Wimbledon champion struggled in the first set and lost four straight games from 2-2, including two breaks to love on his service.
Dulgheru raced into a 5-2 lead in the first set before Zheng broke back to only to lose her own service and the opener.
She had to retire in the fourth round of the Australian Open in the first set of her clash with another Russian, Maria Kirilenko.
Leading 5-2 in the first set, the outgoing World No.1 allowed Williams back into the game with the American racing into a 6-5 lead.
Venus struggled with her serve in the first set, making five double-faults, but still won it easily as both players went for their shots.
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