In the clinical trial results released today, that translated to a less frequent dosing.
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In the clinical trial presented at ACC, there was 1 extra stroke for every 25 people, and a major stroke for every 40.
The most common adverse reactions in the clinical trial included injection site reactions, flu-like symptoms, nausea, headache and elevations in liver enzymes (serum transaminases).
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Some patients in the clinical trial suffered an increased heart rate and a condition called metabolic acidosis, which can lead to hyperventilation, fatigue and anorexia.
In February 2011, he enrolled in the clinical trial at Johns Hopkins School of Medicine for one of the Bristol-Myers therapies, which are infusions given every two weeks.
Although the resulting vision is not the same as when these patients had normal vision, investigators involved in the clinical trial of the Argus II are eager about the approval.
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The scientists are recruiting volunteers to take part in the clinical trial at four hospitals - University Hospital of Wales in Cardiff, Guy's and St Thomas NHS Foundation Trust in London, Bristol Royal Infirmary and Royal Victoria Hospital in Newcastle.
Explanations for this include the fact that it is possible that the levels of antibody titers may have been suboptimal in the majority of the smokers in the previous clinical trial or that the 12.5% reduction in binding may not be sufficient to lead to improved abstinence rates.
It means that although modern medicine treats the 83 year-old diabetic patient with hypertension similarly to the 45 year-old athlete with hypertension, based on them being grouped together in the same clinical trial, in the future, care will be personalized based on what worked best for millions of similar patients previously.
In the 1990s clinical trial used to approve IL-2, 4% of patients died from side effects.
They are to be commended, however, for blazing a trail that others can follow in getting the first clinical trial approved by the FDA, as such approvals should be easier in the future.
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The best minds fighting myeloma worked into the night in the Hilton ballroom and designed the clinical trial that got Velcade, a life-extending treatment, approved by the FDA in 2003.
In a bewildering result, an experimental drug aimed at reducing inflammation in the arteries failed in a big clinical trial but prevented heart attacks, strokes and deaths, according to a press release from the drug's maker.
Although it had been the subject of earlier questions, serious criticism emerged with the publication in 2009 of the TREAT trial, which found no clinical benefit for the drug in patients with chronic kidney disease.
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Patients might drop out of the ongoing clinical trial in order to get the drug, not placebo.
The company has just begun a large-scale clinical trial in the U.S. and hopes to introduce the drug-coated device in 2003, a year ahead of competitors pursuing the same thing.
"Hannah's transplant has completely changed my thinking about regenerative medicine, " he told the Times, adding that he wants to conduct a clinical trial in the United States.
Schering-Plough has changed the start date listed in a government database for the key clinical trial testing the now-controversial cholesterol pill Vytorin, which Schering shares with Merck .
Pfizer has shelved its most promising experimental drug because the medicine increased the risk of death in a giant clinical trial, a disaster for the world's largest drug company.
But attempts to create treatments that harness immune response have mostly resulted in money sent down the clinical trial drain, as well as dashed hopes for patients and investors alike.
The results will need to confirmed in a much bigger clinical trial, the design of which Acorda will need to discuss with the Food and Drug Administration.
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Hartl said that in Europe, several drug firms are set to submit clinical trial data in the next few weeks, with GlaxoSmithKline likely to be among the first.
The Penn Inflammatory Bowel Disease Center has now started enrolling patients in a clinical trial to see if the drugs will be an effective treatment for ulcerative colitis.
The FDA approval for KYNAMRO is supported by the largest clinical trial conducted to-date in the HoFH patient population.
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Last year, Tanner was enrolled in a clinical trial testing the drug, called drisapersen.
That would be the standard approach in a clinical trial.
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Many eye-vitamin formulations currently on the market are based on research conducted by the National Institutes of Health in a project called Age-Related Eye Disease Study, or AREDS. The first phase of the clinical trial, completed in 2001, found that a specific combination of vitamins C and E, along with beta-carotene and zinc, reduced the risk of age-related macular degeneration by as much as 25%.
The UK arm of the trial - part of a larger European one, and funded by the charity Cancer Research UK - will run in all 20 childhood cancer clinical trial centres across the UK, recruiting 160 children over the next four years.
The investigators are now conducting a randomized, controlled clinical trial of RAGE Control in the outpatient clinic at Boston Children's that adds a cooperative component.
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From the time a hint of heart risk first showed up in a clinical trial designed to prove Vioxx was safe for the stomach, Merck has had one response to many of its critics: It would consider data only from controlled clinical trials.
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