Pistorius' career on the track suffered a setback in 2009 when he suffered serious head injuries in a boating accident.
Iraq's official nuclear program was dealt a setback in 1981, when a reactor it was building in Osirak was destroyed in a raid by the Israeli air force.
Beleaguered Guidant, whose stock price has fallen 30% year to date and more than 6% today, suffered a setback in March when its in-house drug-coated stent proved ineffective in clinical trials.
The field then suffered a major setback when an Arizona teenager died in a gene therapy experiment in 1999 and two French boys with SCID developed leukemia in 2002.
In 1992 the firm faced a setback when it lost its biggest customer.
The talks hit a major setback in October 2011 when California State Attorney General Kamala Harris pulled out of the negotiations.
A123, in turn, suffered a big setback when Fisker decreased orders.
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Immunogen suffered a big setback in August when the FDA refused to even consider approving the new T-DM1 breast cancer drug its partner Roche is testing based on its technology.
Even though crossover sales suffered a slight setback in 2009, when the industry was battered by the recession and bankruptcies at General Motors and Chrysler, they have continued to attract new family customers.
He suffered a key setback in recent years when several groups failed to find the right kinds of spherules or otherwise duplicate the results of his team's work and, worse, when a spherule sample from Younger Dryas rocks proved to be only 135 years old.
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Paris could offer additional political and economic incentives to win the contract for Areva, which suffered a major setback recently when it lost a contract in the United Arab Emirates to a South Korean firm.
He said Mr Murray was in the top 10 in the world at the mixed martial arts sport but his career suffered a setback when he was stabbed through the heart outside the Funky Buddha nightclub in central London in September 2005.
Helmut Kohl, Germany 's chancellor, suffered a setback in his campaign for re-election when his Christian Democratic Union was humiliated in a state election in Saxony-Anhalt.
Vance recently suffered a setback when a Manhattan jury decided in May to acquit two police officers that he had charged with rape.
The book effort suffered a setback this week when a federal judge in New York rejected a deal between Google and publishers that would have blessed the scanning of out-of-print books whose copyright holders are unknown.
The coalition suffered a further setback in the Viennese municipal election of October 2010, when the far-right Freedom Party won 26% of the vote, placing it second only to the Social Democrats.
On the field and off, Australian sport is arguably at its lowest ebb since the Montreal Olympics in 1976, when the country failed to win a single gold medal - a setback that led to the creation of the much-admired, and much-aped, Australian Institute of Sport.
Largely dictating the play despite that early setback, the visitors nearly scored in the 17th minute when Baines jabbed a nicely-weighted pass inside for Steven Pienaar who curved the ball casually out of Brad Freidel's reach but against the bar.
Already without batsmen Rahul Dravid and Yuvraj Singh because of injuries, the hosts suffered a setback before the start of play when the experienced VVS Laxman failed to recover in time from a finger problem.
Opponents of repeal suffered a setback when a compromise move by a backbench Labour MSP to include a public commitment to marriage in the replacement legislation was heavily defeated by a Scottish Parliament committee hours after the ballot result was announced.
After that setback, four wickets fell for 24 in five and a half overs, with Bopara's enterprising innings ending when he top-edged a flick to leg and skied a catch to the keeper.
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