Debutant Wood, 24, was not in the original squad but was promoted from the Saxons and offers a line-out option in the absence of Croft.

BBC: Six Nations: Tindall leads England as Wood handed debut

It was approved in the USA last summer where it has become the only non-nucleoside reverse transcriptase inhibitor (NNRTI) - a class of HIV drug - to be included as a first line option in national guidelines.

BBC: Aids drug hailed as 'major advance'

Game-changing innovation requires a different kind of management with a new corporate bottom line in which value-adding innovation is a necessity, not an option.

FORBES: Connect

That prospect has already persuaded companies such as Microsoft, Cisco Systems and Hewlett-Packard to change the assumptions underlying their option schemes in order to reduce their potential impact on the bottom line.

ECONOMIST: The link between pay and performance is weak