To prove the importance of the JAK pathway, someone needed to discover a compound to test the hypothesis that inhibiting the JAK enzyme was of value in treating disease.

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Most recently, the importance of America's alliance with Japan has been underlined by North Korea's preparations to test a long-range missile.

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Niyazov attached such importance to his own epic account of the Turkmen nation that questions on the text appeared in the national driving test.

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