The immune system cells produce a protein called interleukin-6 (IL-6) that contributes to the overgrowth of lymphatic cells and leads to many of the signs and symptoms of Castleman disease.
The bacteria interacts with a molecule called IL-8 which should act as the messenger to rally other parts of the immune system to attack the "invader".
This binding process stimulates production of a protein called interleukin-10 (IL-10) that acts as an anti-inflammatory compound and which helps keep the immune system's response to the infection in check.