Once more: I find it hard to understand how someone who worked as head of Research and Development at Pfizer could possibly deny this basic, universally recognised problem of poor external validity in clinical trials.

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I've always been someone who was very hard on themselves and suffered from low self-esteem.

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We got it built. and I decided this was too hard and there was definitely room for someone to make this simpler.

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"It's not hard to talk about someone who has helped mold me into the woman I am today, " she said.

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And, the only reason you or I accept the dollar in exchange for our hard work or goods is because we trust that someone else will accept it in turn.

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"As someone who disagreed with many of the things she did, I thought long and hard about what to say, " Mr Clegg told the Commons.

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