The record PPV audience of almost 2.5 million was for Mayweather-Oscar de La Hoya in 2007.
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He has defeated Sugar Shane Mosley, Oscar De La Hoya, Miguel Cotto and Marquez, among others.
But while De La Hoya won't be in the ring, his company, Golden Boy Promotions, will.
But that was largely symbolic since De La Hoya was born in the United States.
The De La Hoya-Mayweather bout remains the best-selling PPV fight ever with 2.4 million buyers.
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Mayweather, who took De la Hoya's WBC light middleweight crown, won 116-112, 115-113, 113-115 on the scorecards.
The 29-year-old Philippine's boxing skills may match De La Hoya's in his prime, but his media skills don't.
Bob Arum, promoter of the fight, favours De la Hoya but says the fight could go either way.
His take was more than twice the amount earned by the second highest-paid athlete, pugilist Oscar De La Hoya.
Floyd played De la Hoya, banging his right fist on the canvas after being decked by a body shot.
The cards mistakenly listed Mayweather fighting out of the red corner and De la Hoya out of the blue.
World lightweight champion Floyd Mayweather Jnr, whose father trains De la Hoya, believes either man is capable of winning.
The De La Hoya fight was before Mayweather controlled the revenue streams from his fights through his company Mayweather Promotions.
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Floyd finished with a reconstruction of De la Hoya's defeat against Bernard Hopkins here in Vegas almost three years ago.
De la Hoya, 33, last fought in May when he stopped Ricardo Mayorga in six rounds to win the title.
In 2007, Mayweather eked out a split decision over Oscar De La Hoya, who was past his prime at that point.
Khan also believes working alongside four-weight world champion Pacquiao, who is currently preparing to face De la Hoya, will help his development.
The question for boxing now is whether Pacquiao (48-3-2) can wear the mantle of top dog as well De La Hoya did.
Biolase's competitors include Lumenis, in Israel, and Hoya ConBio, in Fremont, Calif.
In an absorbing rather than classic fight, the judges went for Mayweather's speed and crisper punching over De la Hoya's come-forward aggression.
De La Hoya made things official on April 14 with a made-for-TV retirement announcement in front of the Staples Center in Los Angeles.
Never a stylistically crowd-pleasing fighter, Hopkins hasn't knocked out an opponent since Oscar De La Hoya in September 2004 14 fights ago.
Mayweather is now unbeaten in 38 professional encounters, while De la Hoya, a six-weight world champion, fell to 38 wins and five losses.
The Tuesday of a big fight week is usually designated "open workout" day, but Oscar de la Hoya chose to leave his doors closed.
De la Hoya has been accused by some of looking for the trap-door that night - and Mayweather felt the urge to remind us.
The record pay-per-view audience in boxing was for the 2005 fight between Mayweather and Oscar De la Hoya that generated 2.4 million buys.
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De la Hoya, on the other hand, was given a rapturous welcome, and it was he who came out of the blocks the fastest.
De la Hoya landed with a flurry of body blows in the sixth, although Mayweather was scoring all the time with pot-shots from range.
Pacquiao cemented his claim as the world's best pound-for-pound fighter with convincing knockouts of Oscar De La Hoya in December and Ricky Hatton in May.
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