Vitamin manufacturers are to invited to submit evidence of the efficacy and safety of their high-dose products.
External beam radiation involves zapping a patient with high-dose X rays generated by a machine called a linear accelerator.
Both the high-dose and the low-dose colonies grew more slowly than the undosed ones, gaining 8-12% less weight on average.
Sinai Medical Center, says that one problem with getting patients to take high-dose Lipitor is that some complain about muscle pain.
New restrictions on the availability of high-dose supplements are one possible solution.
Pfizer, with patent protection for Lipitor until 2010, is conducting a study aiming to prove high-dose Lipitor saves more lives than Zocor, from Merck.
Like many people, I had believed that hospice care hastens death, because patients forgo hospital treatments and are allowed high-dose narcotics to combat pain.
It will also provide a stereotactic radiosurgery service (SRS) which involves the precise delivery of a single fraction of high-dose radiation, usually within the skull.
In only one of the trials did the use of stem-cell support and high-dose chemotherapy appear to prolong life more effectively than conventional low-dose treatment.
Pfizer also got a big boost from a backfiring Bristol study that showed high-dose Lipitor was better than Pravachol in some of the sickest heart patients.
The panelists didn't just suggest that Vytorin and Zetia not be used until after patients try high-dose statins, which can cause achiness or more serious muscle problems.
"Don't take a high-dose supplement of any antioxidant during chemotherapy and during radiation because we don't know what the effects will be on your treatment, " he suggests.
CNN: Antioxidants may interfere with breast cancer treatment
But 13% of patients on the high-dose group discontinued because of side effects during the first year, compared with 9% in the lower-dose group and 7.2% on placebo.
Of the 200, 000 or so Japanese women thought to take high-dose pills illicitly for contraception some are smokers, and so at the greatest risk from these older pills.
At present, while high-dose vitamins and minerals are readily available in the UK, over-the-counter sales are already outlawed in most EU countries, leading to a "black market" in vitamins with the UK as its source.
High-dose chronic pain medications are questioned by many pain physicians, and so long-term use of pain medications should be done judiciously and with expert supervision due to the risks associated with this form of treatment.
Nissen's study studied heart patients taking either Pravachol, from Bristol-Myers Squibb (nyse: BMY - news - people ), or high-dose Lipitor, from Pfizer (nyse: PFE - news - people ).
In the study that spent two years tracking 4, 162 patients who had already survived a severe heart attack, those on high-dose Lipitor were 16% less likely to die or have heart attacks than those on standard-dose Pravachol.
Although the older high-dose pill did carry health risks, those arising from the modern pill are generally thought to be minimal, and may well be offset by the protection the pill confers against some forms of cancer.
Roger Blumenthal of Johns Hopkins University, who helps write guidelines for the ACC, says that he thinks muscle pain is a much bigger problem than many cardiologists expect, and that some patients who get switched from Vytorin to high-dose statins could wind up getting switched back later on.
And that's just network television: Several of the friends whom I introduced to "Breaking Bad" chose not to watch the first half of the final season, preferring to get it later in one high-intensity dose.
To make things worse, the high, 80-milligram dose of the drug will probably not make it to pharmacy shelves.
But although the high, 80-milligram dose of Lipitor cut heart attacks compared to the 10-mg starting dose, the increased dose did not cut down on the total number of deaths.
The bottom line is this: why even take the risk of developing a kidney stone-with its attendant pain and suffering-if high dose vitamin C has never been proven to have beneficial effects on our quality of health and risk for developing cardiovascular disease as well as cancer?
In one early test of the medicine, which must be injected, patients whose cholesterol was still too high on the 10-milligram dose of Lipitor had their Lipitor dose upped to 80 mg.
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The optimistic case for Zetia is that adding it to a low dose of a statin will lower cholesterol as much as a high dose of the statin, but without the muscle-weakening side effects.
Ms. Black said profit margins on unit-dose detergents are constrained because the wholesale price is already high, so the retailer is wary of putting too much of a markup on it.
Today Norton's "dose-dense" regimen is common practice for certain breast cancer patients at high risk of relapse after surgery.
Generic drugmaker Ranbaxy Laboratories will make the biggest, 80-milligram dose, which is rarely used because of an increase in side effects with high doses of the drug.
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