This BMC Infectious Diseases paper cited by Wolf showed that mice instilled with various vaginal gels containing microbicide experienced greater herpes simplex-2 infections when challenged three days later.
An estimated 16% of U.S. adults are infected with herpes simplex virus type 2 (HSV-2), which can cause bumps, blisters, or sores on the genitals and surrounding areas, along with pain and itching.