Some patients, such as Wilson Alvarado, develop brain changes called hepatic encephalopathy.

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Alcohol may increase levels of hepatic fat and induce or exacerbate liver injury.

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That compared with weight gain of 36 milligrams a day in mice transplanted through the hepatic vein and 58 milligrams in controls.

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Hepatic fat increased from a baseline of 1 percent to a median absolute increase of 6 percent at 26 and 78 weeks.

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Mipomersen was associated with increases in serum transaminases and hepatic fat.

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Elevations in liver enzymes and hepatic (liver) fat were also observed.

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The new transplant technique is "extremely" gentle on delicate islet cells, causing little or none of the cellular fragmentation that occurs during hepatic portal injection, they said.

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Two injection sites were used: the surface of the small intestine and the hepatic portal vein that connects the pancreas and the liver, where islet transplantation normally is performed.

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