It is modeled on the famous Framingham Heart Study, which helped spot cholesterol and other risk factors for heart disease.
Enhanced cardiovascular protective effects of valsartan in high-risk hypertensive patients with left ventricular hypertrophy: Sub-analysis of the KYOTO HEART study.
FORBES: Two Retractions For Embattled Chief Investigator Of Kyoto Heart Study
Effects of valsartan on cardiovascular morbidity and mortality in high-risk hyper- tensive patients with new-onset diabetes mellitus: Sub-analysis of the KYOTO HEART Study.
FORBES: Two Retractions For Embattled Chief Investigator Of Kyoto Heart Study
Their subjects were participants in a long-term heart study of students from the University of North Carolina who had entered that institution in the 1960s.
Participants came from the Framingham Heart Study, a large study that has been going on since 1948 to look at heart disease risk factors in Framingham, Massachusetts.
Elderly women who lose that much height that fast have a 21% higher risk of hip fracture, said the study, which examined data from over 3, 000 adults from the Framingham Heart Study.
Studies in this area have made use of large, defined cohorts, such as the Framingham Heart Study, to document risk factors in healthy populations, which are then followed for decades to see who develops heart disease.
The Pueblo Heart Study found that although 399 people were hospitalized for heart attacks before any smoke-free laws went into effect, that number dropped to 237 three years after the law's introduction, a 41 percent decline.
CNN: Study: Smoke-free laws may cut heart attack hospitalizations
"Typically, when we do a test or medical study, we're taking a snapshot, " said Dr. Herman Taylor, principal investigator of the Jackson Heart Study at the University of Mississippi Medical Center and one of the scientists enlisted from outside Harvard.
In addition to his many papers exploring the basic science of the renin-angiotensin system, Matsubara was the chief investigator of the KYOTO HEART Study, a randomized, open-labeled trial studying the add-on effect of valsartan to conventional therapy in high-risk hypertension.
FORBES: Two Retractions For Embattled Chief Investigator Of Kyoto Heart Study
Because the Framingham Heart Study is not a randomized controlled trial, it's still not clear if vitamin D is the real reason for the link (the vitamin's levels could drop in unhealthy people for other reasons), or if taking a supplement would lower the risk.
Last March, following accusations by independent bloggers in Japan and Germany, the American Heart Association (AHA) issued an Expression of Concern about five papers published in AHA journals co-authored by the chief investigator of the Kyoto Heart Study, Hiroaki Matsubara, who was a prominent cardiologist and researcher at Kyoto Prefectural University in Japan.
FORBES: Two Retractions For Embattled Chief Investigator Of Kyoto Heart Study
The oncology researchers in La Jolla, Calif. who surf before work have a different approach than the more conservative types who study heart disease in Groton, Conn.
The gene at the heart of the study is the one that caused 18th century patient Charles Byrne, born near Cookstown in County Tyrone and known as the 'Irish giant', to grow to more than seven and a half feet tall.
It indicated that two Merck authors on the VIGOR study knew of three additional heart attacks among Vioxx patients in the study, which had not been disclosed to The New England Journal of Medicine.
In another recent cancer prevention study that found no excess heart risk in Celebrex users, patients only took Celebrex once per day, not twice as in the NCI study, potentially reducing any damaging effects to the heart from Cox-2 inhibition.
The drug is approved to treat chest pain due to heart problems, but a big study failed to prove Ranexa can prevent heart attacks or extend lives.
The company recently completed enrollment in a Phase I clinical study of MultiStem in heart attack patients, and is midway through a clinical study of MultiStem in leukemia and other cancer patients.
Judy O'Sullivan, cardiac nurse at the British Heart Foundation, said the study added to the evidence that alcohol in moderation provides some protection for the heart.
Whereas heart failure is most commonly known as a disease of the elderly, most of the study participants with heart failure were in their 30s and 40s.
CNN: Study: Blacks suffer heart failure at alarmingly high rates
Mysticism of a different kind is at the heart of a new study of Lourdes.
Exercise elevates heart rate much more than mental stress does, meaning the effects of mental stress on the heart may be caused by adrenaline impacting the heart cells, the study authors said.
Nissen's study studied heart patients taking either Pravachol, from Bristol-Myers Squibb (nyse: BMY - news - people ), or high-dose Lipitor, from Pfizer (nyse: PFE - news - people ).
All of the heart patients in the study had one of two bad gene variants discovered last year by DeCode that are believed to increase levels of inflammation in the arteries (see: " Attacking Heart Attacks").
Experts have a number of hypotheses as to why anxiety and heart disease may be linked, though the new research can't confirm that anxiety -- not some other factor -- is the cause of heart disease and heart attacks in the study.
CNN: Study: Anxiety in youth linked to heart attacks later on
Sanjay Kaul, a cardiologist at Cedars Sinai Hospital in L.A. who has been an FDA consultant, says the FDA should now require all cholesterol medicines to either do a big study showing they prevent heart problems before approval or only grant conditional approval and then demand the big study.
FORBES: Why Merck's Niacin Failure Will Scare Drug Researchers
Red wine gained its "heart healthy" reputation after a Danish study in 2000 found red wine drinkers had half the risk of dying from heart disease as nondrinkers.
Packer says this is the first placebo-controlled study in acute heart failure to show a clinical benefit.
The British Heart Foundation is funding a study, which aims to identify the genes responsible for pre-eclampsia.
Heart attack rates in the study may be so low that it will be difficult to prove any difference between drug regimens.
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