In the United States, 30 percent of angiograms find no blockages in the heart arteries, notes Dr. Kim Allan Williams, a professor of medicine and radiology at the University of Chicago.

CNN: Newer heart test may not be better

The abstract notes that one of the deaths was due to acute heart failure at the 10mg dose.

FORBES: Pfizer's Key Drug Walks A Tightrope

"A large part of my heart still resides in the red clay of this place, " notes Robert Shipper.

CNN: Stops and Starts

Eric Topol , the top cardiologist at the Cleveland Clinic, notes that previous studies suggest naproxen might have had a heart benefit.

FORBES: Some Doubt Risk For Bayer's Aleve

Doctors may feel the drug provides little extra benefit compared with an existing heart failure drug, spironolactone, for a much higher cost, notes Eric Topol, chairman of cardiovascular medicine at the Cleveland Clinic.

FORBES: Pfizer's Heart Failure Flop

Morgan analyst Chris Schott notes that drugs like Humira are known to cause worsening of congestive heart failure.

FORBES: Pfizer's Key Drug Walks A Tightrope

Clyde Yancy, medical director of the heart and vascular institute at the Baylor College of Medicine, and another FDA panelist, notes that with drugs, so-called off-label use is often a scandal.

FORBES: Dangerous Ignorance

Sleep patterns disrupted by shift work have been linked to heart disease, but this has also been linked to stress caused by unpleasant jobs, Prof Horne notes.

BBC: NEWS | UK | Magazine | Why should we have eight hours' sleep?

Dr. Marion Moses, director of the Pesticide Education Center in San Francisco, California, notes that at least one commonly used class of pesticides, organophosphates, can adversely affect the heart -- and this effect is just the tip of the iceberg.

CNN: Children face danger in the schoolyard grass from pesticides

He notes that Geodon sales never took off because it causes a change in the electrical rhythms of the heart.

FORBES: ADA Takes On FDA Over Schizophrenia Drugs