Levered and short ETFs, however, can look like they have significant differences, especially when an unknowing investor buys one as a long-term investment.

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Several studies have revealed significant differences in psycho-social development between children whose mothers had participated in MOCEP and those who had not.

UNESCO: Family Literacy Programmes (FLPs)

Even people who agree with one another on many things have some pretty significant differences.

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McChrystal will also have to be attentive to the significant differences between Iraq and Afghanistan.

WSJ: A General for Afghanistan

Apart from the significant differences between the two attacks, Aurora and Stuxnet have done for malware developers what Bannister and Landry did for runners.

FORBES: The Four Minute Malware: Aurora, Stuxnet, and Beyond

But, perhaps surprisingly, only one of these differences, that in physical activity, proved to have a significant relationship with lymphocyte production.

ECONOMIST: The power of negative thinking

Though his nearest competitor is Birdman, 50 sees Jay-Z as his most significant business rival, insinuating that the two have historically played up their differences to create new financial opportunities.

FORBES: Who Will Be Hip-Hop's First Billionaire?

Though significant differences remain between our two plans, Republicans and I have enough cuts in common to balance the budget in seven years and to provide a modest tax cut without devastating Medicare, Medicaid, education, and the environment and without raising taxes on working families.

CNN: 'The era of big government is over'

And I think despite all of our differences in the last two and four years, we have achieved significant things together.

WHITEHOUSE: Press Briefing