Ms. YOLANDA ADAMS: (Singing) I've come through many hard trials, through temptations on every hand...
When people live for many years, even decades, following a cancer diagnosis, it is hard to conduct trials large enough to find any kind of survival benefit to screening or early treatment.
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Only giant clinical trials measuring hard outcomes like heart attacks, strokes and deaths can tell doctors whether a heart drug's benefits outweigh its risks.
But the AHA fails to note that there have been no big randomized clinical trials with hard outcomes that show the benefit of their diet.
"This day of commissioning represents the culmination of months and years of hard work of training, trials and practice focussed on ensuring that Defender is ready to undertake operations around the world whenever tasked, " he added.
Aggar dedicated much of his time last winter to getting fit for the World Championship selection trials and the hard work on land and on the water paid off with a place in the Great Britain squad for the World Championships in Munich.
Common side effects like increased heart attacks--the problem with Vioxx--are hard to discern with conventional clinical trials.
His sentencing, like to complexities of his two trials, was a hard fought legal battle by both the prosecution and his defense.
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The fog of division, discord and blame, made it hard to see what lies ahead but after those trials we all rallied around what was right and acted as one.
But biotech drugs are hard-to-make proteins that will require their own clinical trials.
When the drug began large-scale trials in 1997, Novartis knew that it might be hard to prove the drug was truly effective.
This will cause companies to think long and hard before taking a new CV or other chronic use drug into clinical trials.
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Given that these trials can cost hundreds of millions of dollars, it is hard to imagine that even the biggest companies will be able to afford to run many such programs at the same time.
Now comes the hard part of translating this preliminary result into a vaccine suitable for large-scale human trials.
And it's hard to see how anyone can have a clue if it can get past the FDA once Arena's trials finish.
The trials must be big because there are so many good heart drugs already and proving an additional benefit is hard.
Until recently, some failed antidepressant trials weren't published in medical journals, or were buried deep in the literature where they were hard to find.
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