Last week, hostility against the liquor stores on the edge of the reservation (booze is banned within it) erupted after the bodies of Ronald Hard Heart and Wilson Black Elk were found decomposing in a ditch near the stores.
Only giant clinical trials measuring hard outcomes like heart attacks, strokes and deaths can tell doctors whether a heart drug's benefits outweigh its risks.
Many investors expect that these drugs might be approved, at least in some patients, based only on studies of their cholesterol-lowering potency, not hard proof they prevent heart attacks and strokes.
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In his room at the apartment, Mr. Sen's possessions offered a snapshot of a man described as gentle and hard-working: heart medication, a large box of fudge brownies and several books on learning HTML and business.
It sounds impressive, but in fact, a relatively modest increase in a common ailment such as heart attacks is hard to detect clearly.
Think of all the hard work and all the heart you put into a cause that you believed in for years -- for years.
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It was not an outcomes trial measuring "hard" outcomes such as heart attack or stroke, but instead was a "surrogate" study measuring carotid artery thickness.
The next step is simple, but perhaps hard on the brain and heart-compare what you actually do with what you actually want and examine the differences.
It is supposed to be much more difficult to show a benefit in the "hard events"--heart attack, stroke and death--than in the broader swath of "extra" heart problems that AtheroGenics measured in its trial.
Although the idea of the uncanny valley has been observed, there has not been much rigorous scientific experimental work on it, partly because it's hard to get at the heart of the matter objectively.
The first 10 minutes are NOT to be missed, my heart was pounding so hard I though it would leap out of my chest!
Hard-working fans have poured heart, soul, incredible levels of technical effort, and ridiculous amounts of time into upgrading many classics of the genre with modern graphics, sound, and features.
One might expect that at the ripe old age of 100 the company would be creaking along with brittle bones, weak knees, a bad heart, and finding it hard to get up in the morning.
It's hard to believe that we are in the heart of Europe, only a few hours' drive from Trieste or Vienna.
Instead transcending capitalism requires a critical mass of people who have experienced- not the change of mind that our business schools labor so hard to produce- but the change of heart that we usually associate with a spiritual experience.
After age 50, pushing too hard is probably not good for one's heart or longevity.
If Mr Putin represents a new faction at the heart of power, it is remarkably hard to spot.
But, before your heart bleeds, remember, if it is hard for Stallone it is much worse for women.
Intel's latest Core 2 processor (either 1.6 or 1.8 gigahertz) is at the heart, along with an 80-gigabyte hard drive that measures 1.8 inches across.
This fact hit Windsor hard in 2009, while in a hospital after suffering a heart attack a month after Spyer's death.
The trials must be big because there are so many good heart drugs already and proving an additional benefit is hard.
No special equipment is needed (although a heart rate monitor can be helpful for gauging how hard you are working) and interval training can be done either outdoors or indoors.
To Krumholz, this is part of a larger tapestry of unexpected clinical trial results that should make doctors, patients and regulators demand more hard information about whether drugs reduce symptoms or prevent problems like heart attacks and deaths.
She also said that Sutent was sometimes not suitable for patients with heart conditions and the other three drugs would be very hard for patients to access.
However, Calum Irving, director of the gay and lesbian rights group Stonewall Scotland, said the cardinal's comments made it hard to believe that he had the best interests of children at heart.
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Smoking kills around 430, 000 Americans a year, but in many cases the link with death is hard to prove: for instance, a smoker who dies of heart disease may also be an overeater (or drinker).
Back in the 16th Century, the point where the St Lawrence River tightens became a base for a rogue collection of hard-bitten survivalists, who spent months venturing deep into the heart of Innu territory to the trading posts at Lac St-Jean.
Common side effects like increased heart attacks--the problem with Vioxx--are hard to discern with conventional clinical trials.
My heart pounds when I think of this, and that why I train hard, to make the people happy.
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