Hape moved to The Rec in a cross-code switch from Bradford Bulls in 2008.
"Quality teams take all their chances and we just haven't been doing that, " admitted Hape.
"After the internationals I've put in some of my worst performances for Bath, " Hape told BBC Radio Bristol.
It will also be scrum-half Youngs' first start in the Six Nations and Hape's first appearance in the tournament.
BBC: Six Nations: Tindall leads England as Wood handed debut
Shontayne Hape's late try brought Bath within two scores of their rivals, but Robinson sealed his side's opening win.
Tadulala and Shontayne Hape closed the gap, but Ryan Hall's interception and a Kylie Leuluai try killed the game.
Maddock benefitted when Shontayne Hape made ground through the middle and drew Latham in before passing out for the score.
Hape's try gave Bradford renewed hope but an inexcusable knock-on by Paul Sykes straight from the restart put Bradford back in trouble.
Centre Hape then touched down before Henderson plucked the ball out of the air from Harris' perfectly-judged kick to put the game beyond London's reach.
Stuart Hooper scored for Bath to reduce the deficit to 13-7 at the break before Shontayne Hape and Michael Stephenson added further tries for the visitors.
Hape has played in both of England's Six Nations fixtures this season and has been included in the squad for Saturday's game with France at Twickenham.
The duo helped the Bulls to a 10-6 advantage before Jamie Peacock, Karl Pryce and Shontayne Hape joined in the flurry of tries in the second half.
However, rugby league convert Hape crossed from close range in the 53rd minute and Stephenson found a gap in the left corner to squeeze over four minutes later.
Chris Ashton, Mark Cueto and Ben Foden need the target men of Shontayne Hape and Mike Tindall to repeatedly get over the gain line and provide quick ball.
In my view Tindall and centre partner Shontayne Hape have been underused in attack and when you've got someone like Banahan you need to give him the ball.
The Bulls have started very well and their left side, with David Solomona, Shontayne Hape and Lesley Vainikolo, is the biggest and most threatening unit in Super League.
Also catching the eye was Shontayne Hape, the rugby league convert, who was giving as good as he got in the midfield exchanges against Tom Shanklin and Jamie Robinson.
With his deal at Bath due to expire at the end of this season, the Somerset club's chief executive Nick Blofeld admitted on Friday that Hape could be set to exit.
Hape made his first England appearance in the non-cap, pre-tour game against the Barbarians and has been preferred at inside centre to Bath team-mate Olly Barkley, alongside Mike Tindall in midfield.
Hape finished off Bath's best move of the match to at least put some points on the board, although there were suggestions of a forward pass from Danny Grewcock in the build-up.
After Bath centre Shontayne Hape had been turned over in the tackle, Sarries scrum-half Neil de Kock made a sniping run that ended with American winger Wyles touching down in the corner.
If Eastmond did make the move south he would follow the likes of Shontayne Hape and Chev Walker in swapping the 13-man code for Bath, although Sale Sharks have also reportedly been linked.
Banahan, who took Mike Tindall's place in one of four changes to the side that beat the Wallabies, was paired with Bath team-mate Shontayne Hape in the centres for the first time at international level.
The Irishman looked the favourite to win the race to touch down but some vicious offspin at the last moment enabled Shontayne Hape to get back and just beat the Tigers winger to the ball.
Banahan will form an all-Bath midfield pairing with Shontayne Hape, whom he partnered in Bath's first game of the season at Leeds, when he played at 12, but the two have subsequently shared the 13 jersey.
Wood's inclusion means that over a third of England's starting line-up will get their first experience of playing a Test in Cardiff, with Ben Foden, Chris Ashton, Shontayne Hape, Ben Youngs and Dan Cole also new to the Millennium Stadium Test experience.
BBC: Six Nations: Tindall leads England as Wood handed debut
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