But Stoke improved as the half wore on and went close when Robert Huth's free kick found its way through to Ryan Shawcross and the centre-half's shot on the turn was blocked by two Wigan defenders.
Yannick Jauzion's forward pass denied full-back Maxime Medard a clear run and a Blues chance was blown when Jamie Roberts could not hold Nicky Robinson's pass after the fly-half's 45-metre run.
Sale wasted two good opportunities after Hodgson's fourth penalty before the fly-half's inspired try, feigning an inside lay-off to Elvis Seveali'i, beating Malone with a side-step before sprinting inside Alex Crockett to race over untouched.
And full-back Nick Macleod, who took over kicking duties after moving to fly-half following Hodgson's half-time withdrawal, equalled a club record.
The first came on 24 minutes when, straight after McGillvary had cancelled out Holdsworth's early score, Williams took the Salford scrum-half's pass to cut inside David Hodgson to make it 12-6.
Almost inevitably, for all Arsenal's superiority, it was Drogba who made the first-half's decisive contribution as Chelsea went ahead after 39 minutes.
But Ronan O'Gara's penalty pushed them two scores clear and the outside-half's kick proved crucial after Delon Armitage crossed over for a try with two minutes remaining.
Gloucester struggled to get going in the first 20 minutes, Lamb's two early penalties all but cancelled out when the fly-half's kick was charged down and returned for a try by opposite number Fraser.
The Cottagers came out for the second half to the sound of The Clash's London Calling and whether it was the sound of manager Mark Hughes's half-time team talk or Joe Strummer's rallying call, the home side looked a lot more lively.
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The fly-half's score secured a bonus point for Leinster, while also denying Blues a consolation losing bonus point.
Unfortunately for Thomas he hooked the simple kick left of the posts, spoiling the fly-half's previous good work.
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Wolves had the better of the half's remaining chances, hitting Cardiff on the break through Michael Kightly and Ebanks-Blake.
Dwayne Peel sent a timely message to Wales' selectors with a classic scrum-half's try as Sale regained the lead.
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The talented fly-half's take-and-give with Aled Brew then sent skipper Smith over for a superb score that Tovey himself converted.
Motherwell had the first half's best chance in the 35th minute, when Chris Humphrey outpaced Ryan Stevenson and found Blackman.
It looked like the centre-half's fortunes were changing but a summer of upheaval at Celtic persuaded him to look elsewhere.
Referee Nigel Owens awarded a penalty try but opted not to sin-bin Spice, ruling the scrum-half's infraction was only accidental.
Rees was the catalyst with two eye-catching breaks that owed as much to the scrum-half's quick-thinking as to his swift feet.
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Instead it was West Ham who created the first-half's best two openings.
The fly-half's fourth penalty was his best, the kick sneaking over from wide on the touch-line to take the Scots two scores clear.
Arguably the pick of the half's tries fell to Pierre Mignoni.
BBC: SPORT | Rugby Union | European Club | Montferrand 38-22 Bath
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