Skelton swarmed all over the technically-superior Sprott for 11 and a halfrounds before bringing him down and Williams will be playing a dangerous game going toe-to-toe.
Stricker and Baddeley kept pace through the first half of the rounds to leave all three men deadlocked with nine to play before Woods stepped up a gear.
Sixty percent of myeloma patients die within five years, but Giusti beat the odds, living for a decade and a half through multiple rounds of drug therapy and a bone marrow transplant from her twin sister.
Australian Richard Green, like Stenson a previous Dubai winner, is one shot behind, but with just over half the field to complete their second rounds the position could change on Saturday when play resumes.
Thursday's gusty conditions, which had led to the suspension of play for six hours, meant players in the second half of the draw were out early Friday to complete their first rounds.