Fly-half Toby Flood and flanker Joe Worsley, who picked up injuries in the emphatic 34-10 victory over France on Sunday, are passed fit to play.
Leicester, with South African Derrick Hougaard at fly-half instead of Flood, won 19-15 against Bath, while the Blues beat Sale thanks to a last-minute try from Richard Mustoe.
Fly-half Flood suffered a shoulder injury against France, while flanker Worsley suffered a gashed right thumb.
England flanker James Haskell and fly-half Toby Flood could not hide their disappointment.
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Only a perfect kicking performance by fly-half Toby Flood, who nailed all six of his attempts, kept England in control.
England team manager Martin Johnson will be relieved fly-half Flood came through the clash without injury, as did lock Louis Deacon.
According to the National Weather Service, nearly half of all flood-related deaths occur in vehicles.
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The Tigers trailed 17-16 at half-time, Toby Flood's early try cancelled out by tries from Danny Care and George Lowe.
In the injury-enforced absence of Jonny Wilkinson and Toby Flood, uncapped Leicester fly-half Sam Vesty and Brive's Andy Goode were selected ahead of Cipriani for the senior squad.
The hosts were fortunate to be 6-6 at half-time, courtesy of Toby Flood, as South Africa dominated but managed only two Morne Steyn penalty kicks.
He last played international rugby nine months ago when he replaced Toby Flood during the 33-10 victory over Ireland and has seen Danny Cipriani and Flood take over England fly-half duties during the second half of this year.
Case in point: fewer than half the residents in flood and hurricane-prone areas were insured against water damage from Hurricane Katrina and Hurricane Sandy.
Flood was replaced just before half-time on Sunday after landing awkwardly on his shoulder in the lead up to Worsley's try.
Flood played at fly-half in England's last match, the defeat by New Zealand in the second Test in Christchurch in June.
Boro continued to shade the first-half and could have gone ahead when Flood teed up Killen for a shot which he wastefully lofted over the bar.
Cipriani will compete with Leicester's Toby Flood for the fly-half shirt while Abendanon, who has been in eye-catching form for Bath, will provide extra competiton at full-back.
Saracens were leading the Tigers 6-3 at the interval in Saturday's match, but the league leaders were overhauled with Toby Flood kicking four second-half penalties for the visitors.
England are still very negative, but the midfield balance was better with Riki Flutey and Mike Tindall, while Toby Flood offered something at fly-half when he replaced Andy Goode.
"The defensive set in the last five minutes of the first-half was vital, " said the Englishman, whose team had already been hit by Toby Flood's 23rd-minute score.
Jonny Wilkinson is out with a hamstring injury, meaning Newcastle colleague Toby Flood gets another start at fly-half.
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Meanwhile Jonny Wilkinson has been reflecting on his demotion to the England bench, with Toby Flood preferred to the Toulon fly-half.
Toby Flood replaces Charlie Hodgson at fly-half, Jamie Noon partners Mike Tindall at centre while Mathew Tait and Tom Varndell come into the back three.
But the reliable boot of Toby Flood and a late try from scrum-half Ben Youngs allowed Leicester to cruise to victory.
Flanker Waldrom then charged through and over to finish off Flood's break with the outside-half kicking his fifth conversion of the game.
Flood, who can also cover fly-half, was drafted in after Noon suffered a tournament-ending knee ligament injury in Friday's defeat by South Africa.
Murphy's try and another Flood penalty gave the Tigers an 11-3 half-time lead, but it could have been much closer had Ben Cohen not seen a try disallowed for a knock-on earlier in the move.
It said around half the 140, 000 people living in the camps are in flood-prone rice fields and low-lying coastal areas.
Leicester just about kept Miles Benjamin out, and their resilience was rewarded when Flood cut the gap to one point during first-half injury-time despite his side being down to 14 men with Jordan Crane in the sin-bin.
Flood, signed by Leicester recently predominantly as a fly-half, has started only two of his 17 England Tests at number 10.
Flood is likely to vie with Danny Cipriani for the England fly-half berth in the November internationals.
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