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Murray's path through the draw could potentially take in Hajek, Gilles Simon, Sam Querrey, Fernando Verdasco, Nadal and Federer.
BBC: Andy Murray to play Czech Jan Hajek in Wimbledon opener
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Hajek does have some form, however, after winning a Challenger event on clay in his home country last month.
BBC: Andy Murray to play Czech Jan Hajek in Wimbledon opener
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Russian second seed Mikhail Youzhny defeated German Andreas Beck 6-3 6-3 to reach the third round, where he faces Jan Hajek of the Czech Republic.
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Second seed Mikhail Youzhny, the runner-up for the past two years, also moved into the semis with a 6-1 6-3 win over Czech Jan Hajek.
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Jan Hajek followed suit to thrash Paul Capdeville 6-0, 6-2, 6-1.
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The fourth seed, who was drawn in the same half as world number one Rafael Nadal, will take on the 26-year-old Hajek for the first time.
BBC: Andy Murray to play Czech Jan Hajek in Wimbledon opener
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No. 94 Jan Hajek crushed Mikhail Kukushkin 6-3 6-2 6-4.
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Murray should have few problems with his first-round opponent as Hajek has made just one appearance at Wimbledon, losing in the first round in 2007, and his best results have come on clay.
BBC: Andy Murray to play Czech Jan Hajek in Wimbledon opener
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But 19th seed Mardy Fish , runner-up to Roger Federer in Cincinnati , recovered from a mid-match wobble to overcome Jan Hajek 6-0 3-6 4-6 6-0 6-1 and 23rd seed Feliciano Lopez beat Santiago Giraldo in straight sets.
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