First, for most countries the greatest long-term fiscal threat comes from unfunded retiree benefits, which by their nature are indexed to inflation.
Global warming is the greatest long-term threat to our planet's environment.
But research shows that a holistic approach that treats both body and mind through a combination of medication and talking therapy offers the greatest long-term benefits.
According to additional research by JPMorgan, the greatest long-term fallout would be a drop in the value of financial markets, which can create an economic drag.
Over the long term, the greatest risk to bondholders is that sales of cigarettes could collapse.
When exchange-traded funds were introduced in 1993, they were one of the greatest innovations for long-term investing in decades.
Mortgage REITs, which use short-term debt to buy longer-term mortgage securities, also are at the greatest risk if interest rates rise because that would increase their short-term borrowing costs and cut the value of the mortgage bonds that they hold, possibly resulting in losses and reduced dividends.
Indeed, Reagan, himself, deemed the rise in the national debt during his term to be the greatest disappointment of his presidency.
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Research shows that the greatest investment gains over the long term typically accrue to those who buy stocks when they are inexpensive.
Continued strength in these markets poses the greatest upside risk in the near term, but weaker-than-expected prints in the regional manufacturing indices earlier this week suggest that manufacturing activity has slowed more substantially than previously expected.
As quality metrics are devised and set I will remind policymakers that people with disabilities needing long term care represent the single greatest and growing expense for public insurance.
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Even in Europe, where the focus on deficit reduction is greatest, the impact will in the short term be relatively modest (see article).
Customer-centric firms celebrate the heterogeneity of their customer bases and focus their efforts on those subsets that are likely to provide the greatest bang for the buck over the long term.
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In the long term, Domscheit-Berg argues, WikiLeaks' greatest impact may not be any particular document release but the entire movement of second-generation sites like OpenLeaks that it has spawned.
"The really successful charities combine raw passion for their cause with a clear-eyed view of where they will get the greatest return on their fund-raising investment over the long term, " he says.
We believe that the long-term outperformance of low-risk portfolios is perhaps the greatest anomaly in finance.
If I were to pick one, I'd say the greatest contribution of this report was that it shows how the long-term health of our public finances is linked to the long-term health of our health sector.
That cynicism could pose the greatest threat to Mahathir's attempts to reassert his authority over the long term.
These additions reflect what Defra believes are areas which are at greatest risk from the geographic spread of TB "in the short to medium term".
But the greatest boon of all to food security and to the environment in the long term may be the ability of new crop varieties to tolerate periods of drought and other water-related stresses.
Despite his authoritarianism and his destruction of many of his country's institutions, had Mr Fujimori not sought that term, many Peruvians would have hailed him as one of their greatest presidents, because of his success in the early 1990s in crushing terrorism and hyperinflation, and in reforming the economy.
The greatest risk in the carry trade, however, is a sudden increase in long term interest rates.
As employed by Warren Buffett, the greatest investor of all time, value investing is the only winning strategy for the long term.
Yet how can the term rookie be applied to a 32-year-old superstar who is the greatest relief pitcher in Japanese history?
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