Stosur, who had nine double-faults and 56 unforced errors, has never gone beyond the fourth round at her home Grand Slam, lost in the first round last year and also lost in her first matches at warm-up tournaments this year in Brisbane and Sydney.
Perry admitted he was hoping to avoid O'Sullivan in the early round of the Grand Prix.
The 19-year-old, playing in the fourth round of a Grand Slam for the first time in his career, looked nervous at the outset.
World No. 41 Lisicki, who has reached the fourth round of a Grand Slam for the first time, will next face ninth seed Caroline Wozniacki.
World number one Wozniacki was rarely troubled during the 58-minute match as she reached the third round of a Grand Slam for the 13th successive time.
Stephens' 6-3 6-2 win against France's Mathilde Johansson meant the 70th-ranked 19-year-old reached the fourth round of a grand slam for the first time in her career.
The U.S. will have four women in the fourth round of a grand slam for the first time since 2004 after Jamie Hampton and Bethanie Mattek-Sands joined world No. 1 Serena Williams and Stephens.
Polish eighth seed Agnieszka Radwanska beat Kazakhstan's world No. 57 Galina Voskoboeva 6-2 6-2 to set up a clash with Germany's rising star Julia Gorges , who is in the fourth round of a grand slam for the first time.
She may never have progressed past the second round of any grand slam singles event, but she did break into the top 30 for the first time and reached her first WTA Tour final at the UNICEF Open in the Netherlands.
Unseeded, she reached the last four at the US Open, having never passed the second round at any previous Grand Slam.
For the first time in his career Monday, Nadal lost the first set of a first-round match at a Grand Slam tournament.
Isner, a winner of five titles since turning pro in 2007, has never advanced beyond the fourth round of the Melbourne grand slam.
The 18-year-old's previous best at a grand slam was reaching the second round of Wimbledon in 2011, but she now is one match away from the last eight.
Whilst recording a short interview with him this morning, I sensed that he would have preferred a day of relaxation in the MGM Grand to a six-hour round trip, even in a comfy limo.
Imagine: You could be the lucky grand prize winner who takes home round trip airfare to San Francisco for you and a friend, three nights at a swanky hotel, a WiFi-equipped Samsung WB850F digital camera to capture the fun, and a pair of coveted Expand tickets.
But if they are not faced down the Doha trade round is dead, the grand strategy in tatters.
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With its grand casino, fabulous weather almost year round and famous music festival, which inspired the Eurovision Song Contest, San Remo rivalled Cannes as a glamorous beach destination for starlets and millionaires in the 1950s and 1960s.
Azarenka had retired during previous Grand Slam matches, including a fourth-round match against Serena Williams at the 2009 Australian Open.
Victory on Saturday would have seen the 23-year-old climb to a career-high 15th in the rankings, up from 19, but -- just like in the fourth round of January's opening grand slam Down Under -- she had no answer to Radwanska's game.
Jenson Button reckons it would be a good idea to hold a grand prix in Moscow after he drove a McLaren round the Kremlin in a demonstration event last weekend.
The 17-round MotoGP World Championship starts with the Spanish Grand Prix at Jerez on March 26.
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The French Grand Prix follows on the weekend immediately after the European round, leaving a week between Magny-Cours and Silverstone for testing.
Grand-Prix racing is another (she usually whizzes round as a passenger).
The fight at the MGM Grand arena settled into a familiar pattern from the third round on as Mayweather made adjustments and started landing some crisp right leads to Guerrero's head.
His comeback continued at Wimbledon as he reached the fourth round -- his best run at a grand slam -- but now his career has again been derailed by what appears to be a serious knee injury.
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Then, Williams lost in the first round, something she had never done at a Grand Slam event.
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