Petr Cech made excellent early saves from Fernando, Mathieu Chalme and Yoann Gourcuff as Chelsea struggled.
Gourcuff's delivery was inch perfect for Ciani to nod home from six yards.
Centre-back Michael Ciani rose unchallenged to head home a Yoann Gourcuff free-kick and put the visitors ahead on the stroke of half-time.
Andrews' heated conversation with the Real Madrid star, was followed by a shoving match in which Richard Dunne and Yoann Gourcuff became involved.
Uruguay coach Javier Aguirre brought on the highly rated Lodeiro in place of Gonzalez shortly after the restart, and Domenech replaced Gourcuff with Malouda.
"There was a low blow with the sending-off of Gourcuff and when things don't go for you they just don't go for you, " commented Domenech.
Four minutes later, Chamakh's fourth Champions League goal of the season drew the visitors level, the Moroccan striker heading home after excellent work by Yoann Gourcuff on the right.
The Czech stopper also had to be alert to beat away a stinging effort from Chalme and another from Gourcuff as Chelsea gave their hosts too much time and space.
At the other end, Gourcuff strode into a threatening position before scuffing his shot into Given's arms and Lassana Diarra then flashed a shot inches wide with the Irish keeper struggling.
Bordeaux were thumped 4-0 when they met the Blues at Stamford Bridge in September but Bellion is sure his side, which includes highly rated midfielder Yoann Gourcuff, will offer more of a threat this time.
However, Malouda was recalled in place of Yoann Gourcuff in a line-up that kept faith with a world class strike-force, spearheaded by Nicolas Anelka, that has failed to register an international goal since last November.
Their first chance came courtesy of a viciously inswinging Wendel free-kick from the right that left Lyon keeper Lloris stranded, but Yoann Gourcuff could only glance over - the young midfielder showing his frustration by kicking the post.
Bongani Khumalo's header from a corner and a bundled finish from Katlego Mphela gave South Africa a 2-0 half-time lead against France, who had Yoann Gourcuff controversially sent off for an elbow on Macbeth Sibaya between the goals.
Despite fielding a much-changed side against South Africa, France still failed to shine and their World Cup was all but over when Yoan Gourcuff was sent off for using his elbow against MacBeth Sibaya - a decision that left Domenech burying his face in his hands.
Franck Ribery was an early threat down the left and his low cross after seven minutes should have been converted by Govou, while playmaker Yoann Gourcuff had few opportunities to showcase his skills - although he almost caught Fernando Muslera out with a free-kick from a tight angle on 17 minutes.
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