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The genetic domino effect that his team uncovered may have less to do with extending life, he says, then with making it possible to survive caloric restriction at all.
FORBES: Starvation--And Long Life--In A Pill?
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In cases where the side-effect has a genetic root, failures could be averted by excluding potential victims from trials and, of course, from treatments after the drug is approved.
ECONOMIST: Biotechnology
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Since such organisms (simple yeasts or bacteria) would carry a brand-new genetic code, they would in effect be new life forms.
ECONOMIST: A new kind of DNA
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Third, researchers have focused on so-called gene-environment interactions, reasoning that some exposures that have relatively weak associations with breast cancer in the general population may have a much stronger effect in subgroups with a specific genetic make-up.
FORBES: After 40 Years Of Research, What Do We Know About Preventing Breast Cancer?
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Dr Moffitt's team (the actual work was led by her colleague, Avshalom Caspi) looked at the effect on intelligence of breastfeeding, but in a genetic context.
ECONOMIST: Intelligence and genetics
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Groups that include Greenpeace and the Union of Concerned Scientists fret that Africa is being manipulated by multinational corporations, in effect serving as one big--potentially dangerous--genetic experiment.
FORBES: Millions Served
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Groups from Greenpeace to the Union of Concerned Scientists fret that Africa is being manipulated by multinational corporations, in effect serving as one big--and potentially dangerous--genetic experiment.
FORBES: Millions Served
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Iceland, in effect, is a huge extended family that can be used to investigate genetic inheritance.
FORBES: Icelandic identifiers
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But the Cystic Fibrosis Trust said the medicine was "transformational", had a "dramatic effect" and that experts say "no other medicine addresses the basic genetic defect in cystic fibrosis".
BBC: Cystic fibrosis: New drug Kalydeco refused for Welsh NHS
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One interesting point about this observation is that it requires both a genetic input (the 7R variant) and an environmental one (the network of friends) to take effect.
ECONOMIST: The genetics of politics