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Derby's best two first-half chances fell to Giles Barnes, who almost reached Gary Teale's cross with Reina stranded.
BBC: CHOOSE A SPORT
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But Gary Teale gave the home side hope with a low, raking shot which Maik Taylor - recalled for his first appearance since January - tipped round the post, although referee Lee Probert signalled a goal-kick.
BBC: SPORT | Football | Premier League | Derby 1-2 Birmingham
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Things got worse for Derby six minutes later when Gary Teale stepped up to try to catch O'Shea offside but only succeeded in giving the Republic of Ireland defender time to pick his spot for his first goal this season.
BBC: Man Utd 4-2 Derby (4-3 agg)