Cadus is using yeast to identify a class of proteins known as G protein-coupled receptors.

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Peroxynitrites contribute to the hyperphosphorylation of tau proteins by oxidating g-protein coupled receptors and trysoine kinase receptors preventing protein kinase C and AKT from inactivating the enzyme GSK3 which is necessary to prevent the hyperphosphorylation of tau proteins.

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At the time, the hot research area was in testing G-protein-coupled receptors, or GPCRS. These proteins transmit chemical signals into a wide variety of cell types.

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