Hendre Fourie, who impressed on the flank in Moody's absence against Samoa, is among the replacements.
Fourie signed for Leeds in 2007, but has had his last two seasons cut short through injury.
De Jongh is one of three international debutants and will form an all-Stormers centre pairing with Jaque Fourie.
However a calf injury suffered in their opening warm-up match meant Fourie missed the reminder of that tour.
"I've qualify through residency and I would definitely play if they wanted me, " Fourie told BBC Radio Leeds.
Fourie will miss two Currie Cup matches and the third Tri-Nations test against New Zealand on 21 August.
The Wasps forward was sin-binned for putting his knee into the back of Springboks scrum-half Fourie du Preez.
Fourie's chances of gaining that first start have increased due to the head injury sustained to captain Lewis Moody.
Fourie is set to undergo further scans on his knee to find out the full extent of the injury.
Fourie is the linchpin of the Leeds side, highlighted by his man-of-the-match display in the 9-9 opening-day draw with Newcastle.
South-African born Fourie qualifies to play for England through residency after moving to the UK with Rotherham Titans in 2005.
Fourie came off the bench to replace the injured Lewis Moody and is hoping to be in contention to face Australia.
"I've signed the papers to say am I now an English player and not a foreigner in the team, " explained Fourie.
The Springboks, who had Jaque Fourie and BJ Botha sin-binned, mounted a final-quarter fightback with tries from Fourie and Gurthro Steenkamp.
Fourie is expected to become England's first choice open-side flanker for the competition, after captain Lewis Moody suffered knee ligament damage.
Initially, it worked -- as Steyn booted a 50-meter penalty before Fourie crossed wide out following a spell of sustained pressure.
Hendre Fourie, who impressed in Moody's absence against Samoa, remains in the 22 and is likely to revert to the bench.
Adrian Jacobs starts at outside centre ahead of Jaque Fourie, who has been named on the bench along with Ryan Kankowski.
Ruan Pienaar has also been switched from his usual scrum-half role to fly-half for the first time, partnering Fourie de Preez.
With Moody expected to miss the first three Six Nations matches, Fourie is the only recognised open-side flanker in Martin Johnson's squad.
George Stowers extended Irish's lead and, after Hendre Fourie pulled one back for Leeds, Tagicakibau's went over again ahead of Luther Burrell.
Du Preez kicked a penalty into space and Jaque Fourie surged clear.
Fourie, 30, joined Leeds from Rotherham in 2007 but missed six months of the season after injuring his bicep in his debut game.
Steyne and Donald shared penalties before Piri Weepu's wayward pass was recovered by the Springboks and Fourie went over to punish the error.
After repeated threats from referee Greg Garner, Leeds skipper Fourie was shown a yellow card for going off his feet at a ruck.
But there was no place in the squads for under-21 stars Jean de Villiers, Fourie du Preez, Enrico Januarie, Pedri Wannenberg and Roland Bernard.
Zane Kirchner will make his debut at full-back, while Odwa Ndungane, Jaque Fourie, Wynand Olivier and Jongi Nokwe also come in to the backline.
"When I signed the papers to be able to play for England in the summer there was a lot of hype about it, " explained Fourie.
But Dave Langford-Smith and Thinus Fourie (14 not out from six balls) scrambled 22 from the final 12 balls to set Scotland their daunting target.
BBC: SPORT | Cricket | International Teams | Botha stars as Ireland beat Scots
"It means a lot to play for England and it's privilege and honour to represent them at such a high level, " Fourie told BBC Radio Leeds.
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