Uruguay international Diego Forlan and Argentina star Sergio Aguero are likely to spearhead Atletico's attacking threat.
At 3-1 down the Uruguay coach surprisingly substituted captain and top scorer Forlan.
Diego Forlan scored a 52nd-minute penalty to make partial amends for missing from the spot in the first half.
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Forlan, who plays for Spanish club Atletico Madrid, scored five goals as Uruguay reached the semifinals in South Africa.
But Italian referee Pierluigi Collina controversially ruled out the goal and Diego Forlan's late winner merely added to the pain.
Forlan, who forced an excellent first-half save from Hugo Lloris after cutting inside and shooting from 20 yards, was impressive for Uruguay.
Van Bronckhorst opened the scoring in a close encounter with a 35-yard piledriver, before Uruguay's Diego Forlan also struck from range to level.
After Giovanni van Bronckhorst's spectacular opener, Uruguay were gifted an equaliser when goalkeeper Maarten Stekelenburg failed to deal with Diego Forlan's long-range shot.
But Barca's joy was short lived as Diego Forlan quickly pulled one back in the 32nd minute, another superb effort from outside the penalty area.
Jamie Carragher misjudged a long ball to let Forlan in, and he found Simao, who drove a top-class finish across Reina into the bottom corner.
Earlier in the second-half, Atletico's Diego Forlan had hit the post.
Forlan ended a disappointing spell with England's Manchester United in 2005 to move to Spain, where he has twice finished as the league's top scorer.
In a first-half lacking in excitement, the Netherlands took the lead when Giovanni van Bronckhorst lashed in, only for Diego Forlan to level from long range.
Diego Forlan finally fashioned a chance for Atletico five minutes before the interval with a shot on the turn that flashed just wide with Reina beaten.
His strike partner Edison Cavani also missed two good opportunities and captain Diego Lugano fluffed a header from a Forlan free-kick early in the second half.
But Diego Forlan pulled one back after 71 minutes -- incredibly Inter's first in 541 minutes -- before the Uruguayan set up Diego Milito for the equalizer.
Atletico Madrid moved further away from relegation trouble with a 2-0 victory at promoted strugglers Xerez, with star strikers Diego Forlan and Sergio Aguero scoring in each half.
Stekelenburg had a clear view of Forlan's swerving strike from 25 yards out and got a hand to the ball, but was still unable to keep it out.
Substitute Ruud van Nistelrooy - who had replaced Diego Forlan - broke down the right and coolly squared the ball for Giggs to wrong-foot the keeper before slotting home.
That all changed before half-time, however, and it was the Dutch goalkeeper at fault as Forlan notched his fourth goal in six games in the finals in South Africa.
Forlan polled 23.4 percent of votes cast by journalists covering the World Cup, to finish ahead of Dutch playmaker Wesley Sneijder (21.8 percent) and Spain striker David Villa (16.9%).
"It's as great as it is unexpected, " Forlan told governing body FIFA's website, revealing that his teammates reacted to his award by throwing him in the hotel swimming pool.
Two of those came in the final 16 defeat to Villarreal and the Spanish side's striker, Diego Forlan, said afterwards that Lovenkrands could be a big star in La Liga.
But the game quickly got bogged down in midfield and there were few chances to speak of until Forlan brought a much better stop from Stekelenburg with a dipping free-kick.
Uruguay international Forlan put Atletico ahead in the 29th minute from a cross by Jose Antonio Reyes, while Argentina's Aguero doubled the lead on 65 with a low shot from 12 yards.
However, the Spanish team were without top Argentine forward Sergio Aguero who was suspended and that seemed to blunt their attack, with Diego Forlan seemingly at a loss without his strike partner.
"I am part of a team and the designated forward, so it is my job to score goals, " stated Forlan, who also knocked out Galatasaray with an extra-time strike in Istanbul at the last-32 stage.
Forlan's tally of five goals left him level with Sneijder, Villa and Thomas Muller, but the German forward claimed the Golden Boot award because he racked up a higher number of assists (three) than the others.
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