Among the largest underlying components of XPH, in trading today Jazz Pharmaceuticals Inc. ( JAZZ) is up about 5.4%, and Forest Labs Incorporated ( FRX) is up about 1.7%.

FORBES: Investors Are "Just Saying No" To Pharma ETF This Week

Reliant's Krivulka wholeheartedly agrees: He points to Forest Labs (nyse: FRX - news - people ) and its blockbuster antidepressant Celexa, which usurped much of Prozac's market share.

FORBES: How A Billionaire Clan Made Money In Biotech

In the past four years, AstraZeneca ( AZN), Pfizer ( PFE), Eli Lilly ( LLY), Bristol-Myers Squibb ( BMY) and Forest Labs ( FRX) have all settled federal charges of marketing psychoactive drugs off-label, at a cost running into hundreds of millions.

FORBES: Bad Side-Effects Ahead For Pharma?

Abbott Labs and Takeda had formed the Lake Forest, Illinois company in 1977.

FORBES: Issues & Ideas

Abbott Labs and Takeda had formed the Lake Forest, Ill. company in 1977.

FORBES: On The Cover/Top Stories