He snatched the ball and slid his penalty past Helton to provide the perfect finale to a wonderful night for Wenger's side.
The only scare for Wenger's side for the rest of the half was a 30-yard piledriver from Micael, which was pushed safely away by Fabianski.
However, within one minute of the break, the script for Wenger's high-fliers took an unexpected turn for the worse when they were reduced to 10 men.
But Arsenal looked anything but under-strength in a vibrant first 45 minutes that brought a host of chances at both ends and a deserved lead for Wenger's side.
Captain Fabregas, who was involved with five of the six goals, was delighted with his team's display to mark 13 years in charge of the north London club for Wenger.
The win was a welcome relief for Wenger after seeing his side lose their two previous home league games, but he refused to get too excited about the Gunners' title chances.
Ronaldo added a second goal after the break, while a late Robin van Persie penalty for the Gunners - after Darren Fletcher was deemed to have fouled Cesc Fabregas - was little consolation for Wenger.
The problem for Arsene Wenger and myself is that the longer you are in the game the more labels are attached to you.
The Frenchman, the rock in Arsenal's solid midfield for the past five years, featured in almost every match for Arsene Wenger's side last season.
Greater challenges will lie ahead for Arsene Wenger's side - but the victory margin was a fair reflection on their superiority in front of an elated Emirates gallery.
But the quality of the younger players at the club speaks for itself and Wenger must take credit not only for their purchase but guiding them through through to the final.
BBC: SPORT | Football | My Club | Arsenal | Why Arsenal came good in Europe
But when Chamakh was brought on for Denilson - Wenger replacing a holding midfielder with a striker - the substitute almost had an immediate impact, only for Mignolet to deny Arshavin after the Moroccan's run and pass from right.
As well as having Eduardo in his squad for Saturday, Wenger said that striker Nicklas Bendtner has recovered from an ankle knock and should be fit.
BBC: Arsenal's Eduardo 'can cope with return to St Andrew's'
Burnley boss Coyle was glowing in his praise for opposite number Wenger before the game - and his players were arguably guilty of showing Arsenal too much respect in the opening exchanges.
"Out of my huge respect for Mr. Wenger, the players and the fans I don't want to go into any details, but unfortunately in this meeting it has again become clear to me that we in many aspects disagree on the way Arsenal FC should move forward, " he added.
The Gunners dominated for long periods despite the absence on the touchline of boss Arsene Wenger, banned for one game for his reaction to the equaliser they conceded at Sunderland on Saturday.
And it would have got even worse for Arsenal manager Arsene Wenger's team had Szczesny not saved a late effort from Carlos Edwards.
"There is still a little chance for Robin van Persie this season, " Wenger said in his programme notes for Saturday's match against West Ham.
"It's very difficult to go out of the Champions League for anybody, especially when you lose at home, you make it difficult for yourself, " Wenger told Sky Sports.
Ultimately, it was a convincing win for Arsenal manager Arsene Wenger's side, which had an unusually strong look to it compared to the line-ups the Frenchman has chosen to field in previous Carling Cup campaigns.
For Arsenal boss Arsene Wenger, who knew defeat would more or less turn the title into a two-horse race between Chelsea and Manchester United, it was an afternoon of very public torture and his body language suggested he is feeling the strain of Arsenal's faltering challenge.
Ferguson, who has managed United for 23 years, believes Wenger's success is further proof that "longevity brings rewards".
"Koscielny is a central defender with great ability who performed extremely well last season for Lorient, " added Wenger.
Almunia is keeping Jens Lehmann out of the starting line-up and Wenger is happy for things to remain as they are.
And, of course, there is the very real possibility that Arsenal will miss out on the Champions League for the first time since Wenger took over in 1996.
"England has clubs like Arsenal, where Arsene Wenger has been for several years, yet has won only two or three championships, " he told a news conference for his present club Palmeiras.
"It will be difficult and edgy until the end but the only thing I can say is that we are ready for a fight, " Wenger said after two goals from Tomas Rosicky put Arsenal ahead against eighth-placed West Brom before defender Per Mertesacker's sending-off led to a penalty by James Morrison.
Wenger admitted his move for Bischoff was "a gamble" because he was battling back from a long-standing groin injury.
Bendtner dragged an angled strike wide before the Tyneside outfit almost punished Wenger's side for not making more of their chances.
Wenger took Ferguson on for a long time, but it is much easier to win these games when you are sitting top of the table.
BBC: SPORT | Football | Premiership | A sad feud that two clubs must stop
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