He has faced starvation, suffered frostbite in his fingers and gangrene in his foot.

BBC: NEWS | UK | Magazine | Faces of the week

The septic shock had left her with heart and respiratory failure as well as dry gangrene of her foot, which would have to be amputated.

NEWYORKER: Letting Go

The Rocky River, Ohio, resident had a toe on his right foot amputated this year after it became infected with gangrene.

WSJ: New Tactics to Treat Artery Disease That Harms Legs