Connacht fly-half Andy Dunne start at fly-half with Ulster's Niall O'Connor as his understudy on the bench.
Connacht made a bright start and fly-half Keatley put the underdogs ahead with an early penalty.
Jonny Wilkinson is out with a hamstring injury, meaning Newcastle colleague Toby Flood gets another start at fly-half.
BBC: Haskell will form part of an all-Wasps back row for England
Harlequins made a superb start, fly-half Chris Malone landing a drop-goal after just 23 seconds while Guest drove in from the base of a close-range ruck.
It may go some way to explaining why every Aussie you meet, including current and former players, expects England's most famous fly-half to start the first Test.
The Welsh region, boasting a dozen players who won the Six Nations with Wales this year, made the better start - fly-half James Hook slotting over a penalty after just three minutes.
And Jackson, making his first start at fly-half, almost sneaked an amazing victory with the last play of the game but he ran out of gas after intercepting a Bath attack inside his own 22.
If that's what it will take for a successor to "30 Rock, " we better start making cars fly.
Ireland coach Declan Kidney has decided to turn once again to Sexton, who was his fly-half at the start of the championship.
"The best way to get a jump-start is to fly on the wings of larger players, " says youngest sibling Rajan Mittal, articulating the brothers' philosophy.
And their cause was not helped by Matt Giteau's shaky start, the fly-half missing a penalty as well as two penalty touches in the opening quarter.
Following Belfast City Council's decision at the start of December to fly the flag only on designated days the DUP has talked of increasing the number of days it flies at Stormont.
BBC: When the union flag can fly at city hall but not at Stormont
Snyder attended the U. of Maryland for a few semesters before dropping out to start a business chartering planes to fly college kids to sporting events.
Masi played at inside and outside centre, as well as on the wing, during the World Cup but will start for the first time at fly-half this weekend.
The Pirates got off to a flying start in the first minute as fly-half Johnny Bentley broke through the Bristol defence and was brought to ground 10 metres short of the try line.
She will fly on Friday from Krasnoyarsk in Siberia to the start of the 636-mile trek at Cape Arktichevsky.
BBC: NEWS | UK | England | Devon | Mum set to start polar ski trek
Fly into people, get physical superiority, then start playing rugby and you'll win.
Trips, most of which start and end in Calgary, can include golf, fly-fishing and wine tasting.
Scrum-half Morgan Parra makes his first Test start alongside Francois Trinh-Duc who replaces David Skrela at fly-half.
The 28-year-old from Wairarapa, in New Zealand's North Island, will start outside Wasps star Danny Cipriani, who is back at fly-half after his rapid recovery from a horrific ankle injury.
Wilkinson missed two kicks at goal, one of them a simple chance in the second half, and Newcastle turned over plenty of possession after a promising start which yielded a fifth-minute penalty for the England fly-half.
The left-hander walked three straight to start the second inning but permitted only Chris Stewart's sacrifice fly.
The England fly-half contender missed the conversion and Leicester went off the boil at the start of the second half, allowing Treviso to briefly raise the possibility of a shock home win.
The loss was the result of a slide in sales of more than a fifth despite a strong start to the year, as both business and holiday travellers ditched plans to fly in or to Asia, for fear of the virus.
James, 31, has not played Test rugby for more than two years and was due to start at inside centre at the Millennium Stadium, although he has starred for Bath at fly-half this season.
They will be rueing the fact that they played Quins on the day that Evans was making his first start since suffering a knee ligament injury on the opening day of the season - the fly-half producing a man-of-the-match display despite playing in the unaccustomed role of full-back.
Banahan gave Bath the perfect start when he latched onto James's grubber kick for the opening try, although the fly-half missed with the conversion.
Shane Geraghty impressed as a replacement during the 30-9 defeat by Exeter Chiefs on Saturday and Mallinder has hinted that the fly-half, who has spent much of the season as Stephen Myler's understudy, could start against Leeds at the weekend.
The Saracens player will start as England's first-choice goalkicker, and will share the responsibility of playing at fly-half with Mike Catt.
An invitation to fly from Edinburgh to Exeter for a winter treat was also found to be misleading because the flights did not start until April.
BBC: NEWS | UK | Scotland | Flybe censured over flight offers
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