If the results of human trials are just as good (not a sure bet), a pill to make fat people thin--one of the holy grails for drug companies--will have been discovered.

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But investors also need to look at where that money is going, lest they find themselves married to an Amazon-like company of fat top lines and ever-thin bottom ones.

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Even what seems thin may be fat: McDonald's (nyse: MCD - news - people ) latest line in healthy-looking salads may contain more fat than its hamburgers, according to a Reuters report, citing information on the company's Web site.

FORBES: Smart Money Still In Fat

The great 19th-century philanthropists laid down their fortunes and set up their foundations in the days when profits were fat, taxes thin and labour weak.

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