One theory, which may explain its failure against breast cancer, is that there may be tissue-specific proteins that spur tumor growth in the absence of VEGF.
Rather than explaining the cycle in terms of market failure, as Keynes did, real business-cycle theory views a recession as the optimal response by households and firms to a shift in productivity.
The so-called advances in organizational design theory have been so grossly over-weighted toward risk management, organizations are now built to prevent failure rather than encourage success.