The Cleveland Clinic's Eric Topol explains why he advised a fund that sold Merck short.
"It's one thing after another, " says Eric Topol, chief academic officer of Scripps Health.
Eric Topol is a prolific tweeter, but he rarely seems interested in cardiology these days.
Cleveland Clinic cardiologist Eric Topol says the number of injured parties could go as high as 160, 000.
When Nissen got back to Cleveland, he showed the results to Eric Topol, the clinic's top cardiologist.
Eric Topol of Scripps Health says his concerns would be the same whatever the outcome of the study.
Eric Topol , the top cardiologist at the Cleveland Clinic, notes that previous studies suggest naproxen might have had a heart benefit.
"Melanie did a good job presenting information, " says Eric Topol, director of the Scripps Translational Science Institute, who invited Ms. Swan to speak.
One person who won't be convinced by ENHANCE: Eric Topol, the noted chief of translational medicine at Scripps Health in La Jolla, Calif.
Eric Topol, a cardiologist at the Cleveland Clinic, says he has reanalyzed that data, and found the difference to be significant, if small.
"It's probably less dangerous than Vioxx, " says Eric Topol from the Cleveland Clinic, "but that's all I can tell with this limited info".
Eric Topol strikes me as the perfect person for this assignment.
The map "took the 3 billion DNA letters and divided them into 300, 000 ZIP codes so you could locate things, " says cardiologist Eric Topol of Scripps Health.
The contrast was as great as the difference between taking a cholesterol drug and a sugar pill, says Eric Topol, chief academic officer of the Cleveland Clinic.
Eric Topol, chairman of cardiology at the Cleveland Clinic, is planning a second trial to see if Acomplia prevents heart attacks, strokes and deaths in heart patients.
An even more powerful stick: limit direct-to-consumer advertising for at least a year, until safety is assured, as has been suggested by the Cleveland Clinic's Eric Topol .
"Physicians are somewhat hardened, " says Cleveland Clinic cardiologist Eric Topol.
When fellow passengers reported chest pains on two recent flights, cardiologist Eric Topol was able to check their heart rhythms with an electrocardiogram app on his iPhone called AliveCor.
The problems started in 2001, when doctors at the Cleveland Clinic, including Steven Nissen and Eric Topol, , published a study in the Journal of the American Medical Association re-analyzing existing data.
According to experts like Eric Topol, director and chief academic officer at Scripps Translational Science Institute, technology like this -- and a slew of other medical wonders -- isn't so far-fetched.
Ever since cardiologists Steven Nissen and Eric Topol pooled clinical trials to warn about the heart risks of Vioxx in 2001, drug companies have fretted about how outsiders will use their data.
Dr. Eric Topol of the Cleveland Clinic and his colleagues reanalyzed data from pivotal clinical trials conducted by the drug companies and found that both Vioxx and Celebrex might have cardiac side effects.
Doctors may feel the drug provides little extra benefit compared with an existing heart failure drug, spironolactone, for a much higher cost, notes Eric Topol, chairman of cardiovascular medicine at the Cleveland Clinic.
"The new APC trial confirms that the safety issue--heart attack and stroke risk---is one that applies to the whole class of Cox-2 inhibitors, " says Eric Topol , chairman of cardiology at the Cleveland Clinic.
Eric Topol, chairman of cardiology at the Cleveland Clinic and one of the most vocal critics of Bextra and Vioxx, says that he saw the FDA panel split mostly between arthritis doctors and others.
Scripps Health cardiologist Eric Topol says testing for single genetic variants may be misleading, as there are likely to be numerous genes that affect the risk of heart disease, diabetes and other serious illnesses.
Eric Topol , one of the country's most well-known doctors and a pivotal figure in the Vioxx litigation, may leave his post as chairman of cardiology at the Cleveland Clinic, according to a Merck spokesman.
The drug companies have argued that the concerns, raised by Dr. Eric Topol of the Cleveland Clinic and his colleagues, resulted from a misguided analysis of existing data, but the concerns have not fully lifted.
Eric Topol of the Cleveland Clinic wrote an opinion piece on the study for Forbes.com, saying, "Virtually every faux pas of clinical trials was committed" (see: " How Not To Do A Clinical Trial").
"You would have thought they would have been more sophisticated in doing trials and would have had all the right checks and balances, " says Eric Topol, chief academic officer at the Scripps Health in California.
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