"The reverse side of the coin is that when new drugs are released, they do not have the proven efficacy that older drugs may, " Barbey says.

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As the efficacy of shifting is proven, and more data becomes available, zanier combinations will emerge.

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Nevermind that no study had verified the efficacy of a three-month dosing regimen, in contrast to the proven five-month program.

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Due to the lack of evidence of efficacy in early clinical trials, the drug (a combination of two proven cardiac medicines) had been rejected by the Food and Drug Administration nine years previously for approval for patients of all races.

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