Ultimately, the IRS whistleblower program needs a commissioner with the vision to realize the enormous promise whistleblowers hold for effective tax enforcement and who will exert strong leadership in this area.

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This is because the cause of a rare form of cancer often can be narrowed down to a single gene, providing a clear target, and because few other effective remedies exist, so that the promise of a new drug can be instantly visible.

FORBES: Mission Improbable

Making a promise to yourself is much more effective than setting a goal.

FORBES: No More Goals! Make Promises Instead

But there are two serious questions that worry genuine doubters: can America's nuclear weapons be kept safe and effective without explosive tests, and can the promise of a comprehensive test ban be comprehensively verified?

ECONOMIST: No more tests

The only problem was that this promise ended up being an intention without effective follow-through.

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Unless, that is, Vertex can make good on its promise to make a second drug which makes Kalydeco effective in some of these patients.

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