"I think what this does unequivocally is end the conversation of whether this is a class effect, " says FitzGerald.
But Merck researchers today referred to the Vioxx issue as a class effect.
They can't say what caused the memory loss and confusion, but it seems to be a class effect and a rare event.
In a statement handed out to reporters, Merck said that the class effect might extend beyond these Cox-2 inhibitors, to many older non-steroidal anti-inflammatory drugs.
"It appears that this is a class effect, " New England Journal of Medicine Editor Jeffrey Drazen writes in a blunt editorial accompanying the three studies.
Those seat-of-the-pants estimates tend to make a class effect seem likely.
Researchers at Merck (nyse: MRK - news - people ) now say that the cardiovascular effects that caused Vioxx to be pulled from the market were part of a "class effect, " which may extend at least two other similar medicines.
Once this reform is fully in effect, middle-class families are going to pay less for their health care.
WHITEHOUSE: Tele-Town Hall: The Affordable Care Act & Seniors
Having served as a state senator, having then served as a United States senator, I had had a chance to see how economic policies were having an effect on working-class families and middle-class families for a long time.
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While the federal class-action law has not necessarily had an effect on the types of industries that are affected by class-action cases, there has been a decline in cases that have, for example, led to an Illinois law being applied to an insurance contract in Alabama, Frank adds.
Opponents will argue that the wealth of the upper class should have no effect on the lower classes.
Certainly, if 750, 000 Americans lose their jobs, that could have an effect on the size of the middle class.
The effect of the diaspora on the entrepreneurial class in Haiti could have a greater financial impact on the country than remittances or foreign aid.
Independent experts who do this for a living have said that this jobs bill will have a significant effect for our economy and middle-class families all across America.
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Cuomo said other measures include tax breaks for small business, corporations and middle class families that will take effect not in the budget being negotiated now, but in the 2014-15 budget, which includes the election year for Cuomo and lawmakers.
In practice, this accord would have the effect of imposing new limitations on a whole class of promising anti-missile systems.
This part is where the GOP controlled state houses legislate using the funds of the middle-class and the poor to give effect to the policy changes that will benefit business and the wealthy.
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The most powerful solar flares, X-class flares, have the most significant effect on Earth.
In effect, Chongqing and Chengdu have created a new class of urban residents who enjoy the best of both worlds.
More importantly, continued policy focus on income redistribution perpetuates the idea that income inequality is the root of middle class economic problems, rather than the effect, allowing for the continued avoidance of the deep-rooted structural issues in the U.S. economy.
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Merck not only caught up by skipping a stage of trials (a risky move that often backfires), but its Januvia pill emerged with the entire market for the class when the Novartis drug ran into side effect problems at the FDA and was never approved.
I'm reading some reports from the Hill this morning that some people, some of the congressional members are talking about doing a scaled-back health reform bill, not something that is as comprehensive but something that would have more immediate benefits for the middle class, like the preexisting thing going into effect immediately.
For the securities class-action business, the knock-on effect is that the number of suits filed has dropped precipitously.
But what we simply cannot allow is Republicans to take care of the spending bill and leave town because the absolute effect of that would be a tax hike for middle-class Americans.
Isoflavone is a major class of phytoestrogens, naturally occurring chemicals that mimic the effect of the human hormone oestrogen.
And the net effect of it all is that the economy is not working for middle-class families.
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Her team will be anxiously studying the opinion polls over the next few days, to see what effect - if any - the Mark Penn controversy has had on those working class voters, on whom she is depending for victory.
There is a multiplier effect that occurs in a portfolio when index funds are used to represent every asset class.
Early dandies, denizens of the leisure class, spent buckets on personal style, investing hours to achieve an effect of spotless nonchalance.
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