Another early ad the next year for the much more mainstream Apple II pictured a woman preparing a meal, gazing adoringly at her mate working on the Apple computer on the kitchen table.
FORBES: How Steve Jobs' Laughable Early Apple Ads Evolved Into Today's Marketing Marvels
Dating back as early as 112 AD, the route today encompasses archaeological sites, spectacular landscapes, rare wildlife, complete solitude and vibrant cities.
In February, the U.S. Food and Drug Administration issued draft guidance designed to assist researchers in developing treatments for patients in the early stages of AD, before noticeable dementia.
As in the early days of the iPhone, advertisers and publishers will be tinkering with new ad ideas, knowing early successes and missteps can help determine what people respond to best.
WSJ: Advertisers Gather Around as Publishers Tout Bells and Whistles of Apple's iPad
Today Microsoft announced that Pandora, the leading Internet radio service, is coming to Windows Phone in early 2013 with one year of ad-free music.
ENGADGET: Microsoft brings guest user account to Windows Phone 8 via Kid's Corner
The objective for all candidates at this point, he says, is to have as much cash on hand as possible in order to withstand the busy fall campaign season and to recover if something goes awry (such as an attack ad campaign) in early 2008.
Despite the fact that other inhibitors of beta-amyloid have failed in clinical trials, Roche is moving ahead with gantenerumab to see if early intervention in patients at risk for AD can stave off disease.
The mobile ad market is still in its early stages, Kennedy says.
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Anheuser-Busch's Super Bowl ad scramble started in earnest in early December when three Chicago agencies--Omnicom's DDB Worldwide, the Leap Partnership and Fusion IdeaLab--pitched final storyboards.
According to his autobiographical letter Confessio, thought to have been written around 450 AD and first published in the early 9th Century (the Book of Amagh, containing the earliest copy believed to exist, is in the Library of Trinity College, Dublin), an angel appeared in a dream urging him to flee from his enslavement.
Dating from about 800 AD, the stones are associated with early Christian crosses - of which there is one on the isle.
For example, in early 2011 I met the chairman of a top 3 ad agency.
"In the early days of television advertising, the audience accepted the ad character merely because it was a big deal to be on TV, " explains Warren Dotz, author of Meet Mr. Product: The Art of the Advertising Character and the upcoming Ad Boy: Vintage Advertising with Character.
And as the supply of original scripted content continues to dwindle and ratings fall accordingly, each of the networks will likely be forced to cut ad rates and offer bonus spots or refunds come early 2008, a scenario that could cost them tens of millions of dollars.
"While Mitt Romney and his allies are counting on big ad buys ... we've made early investments in battleground states -- where we've been registering folks and keeping an open conversation going with undecided voters for months -- to build an historic grassroots organization that will pay off when the votes are counted, " Obama campaign spokesman Adam Fetcher said.
You see, a current ad for the brand shows an ape, then an early hominid seeing a can of Dr. Pepper, and finally a homo sapiens drinking a can of the soda.
FORBES: Dr. Pepper Ad Stirs the Mother of Evolution Battles on Facebook
Sorrell spotted early on the virtues of geographic diversity, a hedge against the cyclical swings of the ad industry.
Analysts said MySpace's ad-matching platform is an industry first, but it's too early to say how successful it will be.
The trick will be to attract enough users in the early days with the promise of free music, then persuade them to upgrade to the ad-free subscription option.
Then she heard a radio ad about a new drug trial for women with low libido and joined up in early 2003.
The latest digitally-driven marketing meme caught fire among the early adopter crowd late this Summer and is a hot topic of conversation at the New York ad fest this week.
FORBES: Advertising Week 2012: Get Ready For The Native Ad Wave
Indeed, a study early last year found that purchase intent after viewing iPad ads was 59% higher than the print ad.
FORBES: Why Apple's New iPad Will Transform Online Advertising
Google's new ad platform, which grew out of its 2007 acquisition of Adscape Media, has operated in beta since early 2008.
De Halleux, whose company has been involved with AdSense for Games since its early stages, says Google's platform appealed to Playfish because social games scale quickly and Google has a large ad sales team.
Dr Tomber said that it has always been presumed that the flow of the trade between Rome and India lasted between the 1st Century BC through to the end of the 1st Century AD, but that there is growing evidence that this trade continued much longer, into the 6th and early 7th Century - although not necessarily continually.
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