Dupuis made it 2-0 about 10 minutes later following a mad scramble in front.
Coach Dan Bylsma plans to use Jokinen to center wingers Pascal Dupuis and Chris Kunitz.
James Neal had a goal and three assists, and Pascal Dupuis scored twice for Pittsburgh.
He will take on Stefan Koubek in the last eight after the Austrian thrashed Anthony Dupuis 6-1 6-2.
Dupuis had five goals and two assists in the series, earning at least one point in all six games.
Dupuis netted the Penguins' lone goal only 34 seconds later, but the Penguins couldn't build momentum off of it.
Dupuis added a short-handed goal at 8:07, Crosby followed at 8:39, and Iginla scored on a power play at 9:53.
Pittsburgh forward Chris Kunitz snapped a shot at Nabokov that clattered off his linemate, Pascal Dupuis, and skipped past Nabokov.
Krajicek will meet Jarrko Nieminen in the last eight after the Finn beat Anthony Dupuis of France 7-6 2-6 6-4.
Joe Vitale raced along the right wing boards and flung the puck in front to Dupuis, who redirected it past Nabokov.
Dupuis 10 (Kunitz, Crosby), 7:10. 2, Pittsburgh, Kunitz 15 (Neal, Crosby), 13:46 (pp). 3, Pittsburgh, Kunitz 16 (Neal, Crosby), 16:41 (pp).
Fleury made 32 saves and didn't get a chance to really relax until Pascal Dupuis' empty-net goal in the final minute.
Mirnyi, the second seed from Belarus, went out in the second round, going down 7-6 6-3 to Frenchman Anthony Dupuis .
Jarome Iginla and James Neal each scored twice, Crosby, Chris Kunitz and Pascal Dupuis added goals, and Tomas Vokoun made 30 saves.
Jarome Iginla tied it in the first, and Pascal Dupuis made it 2-2 in the second for Pittsburgh, which got 35 saves from Vokoun.
Dupuis gave the Penguins their second lead of Tuesday night 41 seconds into the third period when he tipped in a shot from Chris Kunitz.
Bortuzzo earned his second assist of the season on Dupuis' goal.
Malkin added a tying goal in the second, and Brandon Sutter and Pascal Dupuis provided the Penguins with a pair of one-goal leads they couldn't protect.
Dupuis gave the Penguins their second lead of the night just 41 seconds into the third period when he tipped in a shot from Chris Kunitz.
"We needed two goals to win, one in regular time and one in the shootout, and he got both of those, " Pittsburgh forward Pascal Dupuis said.
Pascal Dupuis scored twice, Marc-Andre Fleury made 26 saves, and the top-seeded Penguins opened the playoffs with a 5-0 romp over the New York Islanders on Wednesday night.
Craig Adams bullrushed Nabokov at the left post, setting off a chaotic sequence that ended with Dupuis smacking the puck out of the air from 10 feet out.
The smile grew wider seconds later, when the Penguins won the ensuing faceoff, and Pascal Dupuis' crossing pass gave Crosby a wide-open net for the goal at 12:06.
Pittsburgh wasted no time against the Islanders, beating Evgeni Nabokov four times in the game's first 22 minutes, including goals by Letang and Dupuis 32 seconds apart early in the second period.
Dupuis followed by pouncing on a rebound off Mark Eaton's shot from the point to push Pittsburgh's edge to 4-0 and send Nabokov skating slowly to the bench in favor of Poulin.
Pascal Dupuis scored in the second period for the Penguins, who lost for the second consecutive night after 15 consecutive victories, two shy of tying the NHL record for longest winning streak.
Dupuis put them up 1-0 just over 7 minutes in when his shot from the goal line clanked off the post, smacked the back of Nabokov's pad and went into the net.
Pascal Dupuis scored twice, Marc-Andre Fleury tied a franchise record with his sixth career shutout and the Penguins showed few weaknesses in their quest to bookend the Stanley Cup they won in 2009.
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