In addition, biotech firm Dipexium Pharmaceuticals is trying to revive the frog drug with new trials.
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Insurers are far more willing to deny coverage for an obesity drug with modest efficacy.
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Ranbaxy is also codeveloping an antimalarial drug with the Geneva-based nonprofit Medicines for Malaria Venture.
In this case it was fen-phen, the diet drug with potentially devastating side effects.
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Dr. Grana says she discusses the drug with all her patients who are eligible to use it.
In the fall, rogue FDA researcher David Graham pointed to Crestor as a drug with potential safety problems.
The thought of exposing patients to a drug with these side effects for many years has to be worrisome.
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Head-to-head comparisons of a new drug with existing therapy requires extensive clinical trials.
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Natale and his colleagues used DNA microarrays to compare tumors that were hurt by the drug with those that weren't.
But Crooke plowed ahead, embarking on a 53-patient trial combining his lung cancer drug with traditional chemotherapies Carboplatinum and Taxol.
In contrast, an earlier trial testing of the drug with chemotherapy in colorectal cancer did seem to indicate a survival trend.
Merck doesn't get that all to itself--it shares that drug with London's AstraZeneca (nyse: AZN - news - people).
For the stroke compound, dabigatran, the FDA has requested close monitoring of the use of this drug with regard to kidney function.
To fix these problems, Ketek grapples onto a second spot inside the bacteria, so bacteria can no longer escape the drug with a single mutation.
But there is a wide gap between a drug with a few warts and one that is doomed for the pharmaceutical scrap heap.
Ando says he didn't know much about Celltech until Pharmacia struck a deal to co-develop a rheumatoid arthritis drug with the British firm.
When assessing the merits of a generic drug with a unique drug delivery technology, the most significant risk of course is patent protection.
To fix these problems, Ketek grapples onto a second spot inside the bacteria, so the bugs can no longer escape the drug with a single mutation.
The company does have a promising pipeline, however, including Vardenafil, an anti-impotence drug with fewer side effects than Viagra, expected to go on sale next year.
While Pfizer is racing to file the drug with the FDA, it will probably file the stomach and kidney cancer data for the drug at the same time.
If the protein really could be turned into a drug with both contraceptive and anti-microbial properties, the idea of which many experts are skeptical, it could have wide appeal.
The researchers said their findings demonstrated that further trials should now be carried out on this drug with a view to making it available to patients within a few years.
During that time, Clark may only get to launch one drug with really big potential: Gardasil, a vaccine for the human papilloma virus, or HPV, which causes cervical cancer.
Sarepta, the developer of a new muscular dystrophy drug with extremely promising results, saw its shares gain more than any other medical stock in my monthly scan of biotech, pharma, and medical device stocks.
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With its vote, the advisory panel is suggesting that hydrocodone be moved from its current classification as a Schedule III drug -- a drug with moderate abuse potential -- to a more restrictive Schedule II classification.
To be specific, Merck (MRK) will test a beta-amyloid precursor protein site-cleaving enzyme, or BACE, inhibitor, which the drugmaker notes is the first drug with this type of mechanism to advance to this stage of clinical research.
There is little political upside for the agency to approve an obesity drug with marginal efficacy if there is any chance, even a remote one, that it will be linked to increased cancer rates in the future.
However the dosages used in the trial, 350mg three times a day, were higher than those normally recommended - and the prescription antidepressant compared against it is an old drug with more side effects than the latest varieties.
The hormone was prepared from human pituitary glands recovered from cadavers, and the absence of rigorous collection guidelines and purification procedures permitted contamination of the formulated drug with the agent that causes Creutzfeldt-Jacob disease, the human equivalent of "mad-cow disease, " or bovine spongiform encephalopathy (BSE).
TCI, because once a company has registered a drug with the authorities (a process that restricts the ways that the drug may be made to those that are filed with the application), it takes too much time and money to put other technologies in place.
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