Researchers say the studies were too complicated to point the finger at any particular drug or drug combo.
People taking the drug combo were more likely to report nausea, headache, constipation, dizziness, and vomiting than those taking a placebo.
In November, a tiny company called NitroMed unveiled results showing that its drug combo, BiDil, reduced deaths due to heart failure by half.
Porges points out that because of the side effect issues, doctors may choose to try Copaxone instead of Avonex as half of a drug combo.
The drug combo did decrease the progression of cancer by 15% to 8.9 months and had a 21% improvement in the response rate of patients.
For one thing, the fact that changes in sweat chloride, which should be evidence of the effectiveness of the drug combo, are not significant is a concern.
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While the drug combo did meet the first goal of increasing progression-free survival, it failed to prolong overall survival beyond what is normal for patients on chemotherapy without Erbitux.
He said that one of the problems with fen-phen, a diet drug combo that wound up causing heart-valve problems, was that doctors were too eager to hand them out.
Thanks to an unusual joint venture between drug firm GlaxoSmithKline and the World Health Organization, a potent and affordable new malaria drug combo called Lapdap could reach the hospital within a year.
In particular, researchers will re-analyze a previous big trial of Erbitux as initial colon cancer treatment to see if the drug combo worked better in the subset of patients who don't have kras mutations.
Thanks to an unusual joint venture between the pharmaceutical company GlaxoSmithKline and the World Health Organization (WHO), a potent and affordable new malaria drug combo called Lapdap could reach the hospital within a year.
But analysts still expect a torcetrapib pill to lag behind the combo drug.
The combo drug is tentatively named Vytorin, and results of an 800-person trial were to be revealed at a medical conference on Mar. 8.
Merck and Schering-Plough sell the cholesterol drug Zetia and Vytorin, a combo pill of Zetia and the generic drug Zocor.
Merck (nyse: MRK - news - people ) and Schering-Plough (nyse: SGP - news - people ) sell the cholesterol drug Zetia and Vytorin, a combo pill of Zetia and the generic drug Zocor.
Vertex has started a combo-drug strategy, too, but it could still lose its early advantage.
Among them were the highly touted cholesterol drug Tredaptive and a combo pill for patients with diabetes and high cholesterol called MK-0431E.
An initial human test of the combo--chemotherapy drug idarubicin and Millennium Pharmaceuticals' multiple myeloma drug Velcade--is under way at the University of Kentucky.
But Vytorin is a combo of Zocor and another drug, Zetia, and has never been proven to prevent heart attacks.
For the first time, Merck and Schering-Plough have released details of how a key study of their cholesterol drug Zetia, also used in the combo pill Vytorin, wound up being delayed for more than a year after its findings were originally expected.
The study failed to prove that Vytorin, a combo pill of Zocor and the drug Zetia, did any better at preventing heart-attack-causing atherosclerosis than older medicines.
Vytorin is a combo pill of Zetia and the generic drug Zocor.
Then he botched the handling of a study of his most important product, the Schering-invented cholesterol drug Zetia that is also the basis for the combo pill Vytorin.
The American College of Cardiology panel and two editorials in The New England Journal of Medicine recommended sidelining use of Zetia, a kind of cholesterol drug that works differently from statins, and Vytorin, a combo pill of Zetia and the statin Zocor.
Vytorin is a combo pill of Zetia and the time-tested generic drug Zocor.
The change also applies to the top dose of The combo pill Vytorin, which contains simvastatin and a second drug.
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One is an HIV drug that combines Gilead's Truvada (which itself is a combo of two Gilead drugs to treat HIV) and Sustiva from Bristol-Myers Squibb into a one-pill, once-a-day regimen.
One is an HIV drug that combines Gilead's Truvada (which itself is a combo of two Gilead drugs to treat HIV) and Sustiva from Bristol-Myers Squibb (nyse: BMY - news - people ) into a one-pill, once-a-day regimen.
Full results of the trial showed the Vytorin combo pill did no better at slowing the progression of atherosclerosis than the generic drug Zocor.
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